机构：[1]Department of Plastic Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, China[2]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China内科科室皮肤科昆明医科大学附属第一医院[3]Department of Physiology, Kunming Medical University, Kunming, China[4]Burn Injury Research Unit, School of Surgery, University of Western Australia, Crawley, WA, Australia[5]Department of Human Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia
Keloid scarring is a dermal fibroproliferative response characterized by excessive and progressive deposition of collagen; aetiology and molecular pathology underlying keloid formation and progression remain unclear. Genetic predisposition is important in the pathogenic processes of keloid formation, however, environmental factors and epigenetic mechanisms may also play pivotal roles. Epigenetic modification is a recent area of investigation in understanding the molecular pathogenesis of keloid scarring and there is increasing evidence that epigenetic changes may play a role in induction and persistent activation of fibroblasts in keloid scars. Here we have reviewed three epigenetic mechanisms: DNA methylation, histone modification and the role of non-coding RNAs. We also review the evidence that these mechanisms may play a role in keloid formation - in future, it may be possible that epigenetic markers may be used instead of prognostic or diagnostic markers here. However, there is a significant amount of work required to increase our current understanding of the role of epigenetic modification in keloid disease.
基金：
National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China [81560502]; National Natural Science Foundation of Yunnan Province [2013FB044, 2014FB008]; Health Science and Technology Project of Yunnan Province [2016NS005]; Education Department Fund of Yunnan Province [2014Y165, 2015Z082]; Science and Technology Innovation Team Building Project of Kunming Medical University [CXTD201601]; Doctoral Graduate Academic Newcomer Award of Yunnan Province; Graduate Innovation Fund [2016D02, 2016D11, 2016S76]
第一作者机构：[1]Department of Plastic Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Dermatology, Kunming Medical University, Kunming, Yunnan, China[*2]Burn Injury Research Unit, School of Surgery, University of Western Australia, Crawley, WA, Australia[*3]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
推荐引用方式(GB/T 7714)：
He Yongjing,Deng Zhenjun,Alghamdi Mansour,et al.From genetics to epigenetics: new insights into keloid scarring[J].CELL PROLIFERATION.2017,50(2):doi:10.1111/cpr.12326.
APA：
He, Yongjing,Deng, Zhenjun,Alghamdi, Mansour,Lu, Lechun,Fear, Mark W.&He, Li.(2017).From genetics to epigenetics: new insights into keloid scarring.CELL PROLIFERATION,50,(2)
MLA：
He, Yongjing,et al."From genetics to epigenetics: new insights into keloid scarring".CELL PROLIFERATION 50..2(2017)
生物学