机构：[1]Department of Gastrointestinal Surgery,Institute of Gastroenterology,The First Affiliated Hospital ofKunming Medical University,Kunming,Yunnan,China内科科室消化内科昆明医科大学附属第一医院[2]Kunming Digestive Disease Treatment EngineeringTechnology Center, Kunming, Yunnan, China[3]Department of Gastroenterology,Institute ofGastroenterology,The First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,China,内科科室外科科室消化内科普通外科普通外一科(胃肠与疝外科)昆明医科大学附属第一医院[4]Department of Breast Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming MedicalUniversity, Kunming, Yunnan, China[5]Department of Oncologic Surgery,The First Affiliated Hospital ofKunming Medical University,Kunming,Yunnan,China昆明医科大学附属第一医院[6]Department of Clinical Laboratory, Yunnan TumorHospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China,[7]Department of Clinical Laboratory,The First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,China昆明医科大学附属第一医院医技科室医学检验科[8]Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan,China[9]Department of Cardiology,The First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,China内科科室心脏内科昆明医科大学附属第一医院[10]The First People's Hospital of Yunnan Province (The Affiliated of Kunming University ofand Technology), Kunming, Yunnan, China云南省第一人民医院
Tumor necrosis factor-alpha (TNF-alpha), an important factor in systematic inflammation, is reportedly involved in several cancer types. The TNF-alpha-308 G>A (rs1800629) polymorphism in the promoter region influences TNF-alpha production. The association between TNF-alpha-308 G>A polymorphism and colorectal cancer (CRC) is not fully understood, especially the connections between TNF-alpha-308 G>A polymorphism and clinical features of CRC. In this study, TNF-alpha-308 G>A polymorphism was genotyped in 1140 individuals with or without CRC from Southwestern China. In case-control studies, we found no association between TNF-alpha-308 G>A polymorphism and CRC risk. Analysis of the correlations between TNF-alpha-308 G>A polymorphism and clinical features of CRC revealed that TNF-alpha-308 A allele was associated with higher body mass index (BMI) larger tumor size, and distant tumor metastasis in all CRC patients. Notably, rectal cancer (a subtype of CRC) patients with TNF-alpha-308 A allele had a very high risk of distant tumor metastasis [odds ratio (OR) = 4.481; 95% confidence interval (CI): 2.072-9.693; P = 0.00025]. The association between TNF-alpha-308 A allele and distant tumor metastasis remained even significant after adjusting all clinical characteristics (OR = 7.099; 95% CI: 2.482-20.301; P = 0.000256) in rectal cancer patients. Our results suggested that TNF-alpha-308 A allele was significantly associated with distant tumor metastasis in rectal cancer patients.
基金：
Foundation of Leading Talent Program of Health and Family Planning Commission of Yunnan Province [L-201205]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81460424]; Scholarship Award for Excellent Doctoral Student Grant of Yunnan Province; Foundation of Medical Discipline Leaders Program of Health and Family Planning Commission of Yunnan Province [D-201668]; Foundation of the Institute of Gastroenterology, Research Institutions attached to the Health and Family Planning Commission of Yunnan Province [2014NS122]; Foundation of the Institute of Breast Surgery, Research Institutions attached to the Health and Family Planning Commission of Yunnan Province [2014NS022]; Joint Special Research Funds of Kunming Medical University [2014FZ035]
第一作者机构：[1]Department of Gastrointestinal Surgery,Institute of Gastroenterology,The First Affiliated Hospital ofKunming Medical University,Kunming,Yunnan,China[2]Kunming Digestive Disease Treatment EngineeringTechnology Center, Kunming, Yunnan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhen Li,Shu-an Li,Ya Sun,et al.TNF-alpha-308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China[J].PLOS ONE.2017,12(6):doi:10.1371/journal.pone.0178218.
APA：
Zhen Li,Shu-an Li,Ya Sun,Yu Liu,Wen-liang Li...&Kun-hua Wang.(2017).TNF-alpha-308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China.PLOS ONE,12,(6)
MLA：
Zhen Li,et al."TNF-alpha-308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China".PLOS ONE 12..6(2017)
