机构：[1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming,650093, Yunnan Province, China[2]The First People’s Hospital of Yunnan Province, Kunming, 650031, YunnanProvince, China云南省第一人民医院[3]Medical faculty of Kunming University of Science and Technology, Kunming, 650093, YunnanProvince, China[4]Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam,The Netherlands[5]Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University,Kunming, 650032, Yunnan Province, China昆明医科大学附属第一医院省级研究所云南省消化疾病研究所[6]Faculty of Life Science and Technology, Center for Molecular Medicinein Yunnan province, Kunming University of Science and Technology, Kunming, 650093, Yunnan Province, China[7]Yan’an Hospital of Kunming Chenggong hospital, Kunming, 650501, Yunnan Province, China[8]The First People’sHospital of Zhaotong City, Zhaotong, 657000, Yunnan Province, China
We aim to evaluate the overall survival and associated risk factors for HIV-infected Chinese patients on antiretroviral therapy (ART). 2517 patients receiving ART between 2006 and 2016 were prospectively enrolled in Yunnan province. Kaplan-Meier analyses and Cox proportional hazard regression analyses were performed. 216/2517 patients died during a median 17.5 (interquartile range [IQR] 6.8-33.2) months of follow-up. 82/216 occurred within 6 months of starting ART. Adjusted hazard ratios were10.69 (95% CI 2.38-48.02, p = 0.002) for old age, 1.94 (95% CI 1.40-2.69, p < 0.0001) for advanced WHO stage, and 0.42 (95% CI 0.27-0.63, p < 0.0001) for heterosexual transmission compared to injecting drug users. Surprisingly, adjusted hazard ratios comparing low CD4 counts group (< 50 cells/mu l) with high CD4 counts group (>= 500 cells/mu l) within six months after starting ART was 20.17 (95% CI 4.62-87.95, p < 0.0001) and it declined to 3.57 (95% CI 1.10-11.58, p = 0.034) afterwards. Age, WHO stage, transmission route are significantly independent risk factors for ART treated HIV patients. Importantly, baseline CD4 counts is strongly inversely associated with survival in the first six months; whereas it becomes a weak prognostic factor after six months of starting ART.
基金：
Major Project of Yunnan Provincial Bureau of Education [ZD2015010]; Yunnan Provincial Science and Technology Department [2016FC005]; Foundation of Yunnan Institute of Digestive Disease [2016NS001, 2016NS004]; China Scholarship CouncilChina Scholarship Council [201307720054]
第一作者机构：[1]Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming,650093, Yunnan Province, China[2]The First People’s Hospital of Yunnan Province, Kunming, 650031, YunnanProvince, China[3]Medical faculty of Kunming University of Science and Technology, Kunming, 650093, YunnanProvince, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Ren,Juan Li,Shiyi Zhou,et al.Prognosis of HIV Patients Receiving Antiretroviral Therapy According to CD4 Counts: A Long-term Follow-up study in Yunnan, China[J].SCIENTIFIC REPORTS.2017,7:doi:10.1038/s41598-017-10105-7.
APA：
Li Ren,Juan Li,Shiyi Zhou,Xueshan Xia,Zhenrong Xie...&Kunhua Wang.(2017).Prognosis of HIV Patients Receiving Antiretroviral Therapy According to CD4 Counts: A Long-term Follow-up study in Yunnan, China.SCIENTIFIC REPORTS,7,
MLA：
Li Ren,et al."Prognosis of HIV Patients Receiving Antiretroviral Therapy According to CD4 Counts: A Long-term Follow-up study in Yunnan, China".SCIENTIFIC REPORTS 7.(2017)
