机构：[1]Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK[2]Department ofPsychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK[3]Research Unit, FIDMAG Germanes Hospitalàries – CIBERSAM, SantBoi de Llobregat, Barcelona, Spain[4]Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden[5]Mental Health, Parc Taulí Sabadell-CIBERSAM, UniversityHospital, Sabadell, Barcelona, Spain[6]Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain[7]Department of Radiology, Nihon University School ofMedicine, Tokyo, Japan[8]Department of Psychiatry, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland[9]Department of Psychiatry, The 1st Affiliated Hospitalof Kunming Medical University, Kunming, PR China内科科室精神科昆明医科大学附属第一医院[10]Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London,London, UK[11]Department of Neuroscience, Medical School, Fundação do ABC, Santo André, SP, Brazil[12]ABC Center of Studies on Mental Health, Santo André, SP, Brazil[13]PediMIND Program, Bradley Hospital, Department of Psychiatry, Brown University, East Providence, RI, USA[14]Academic Clinical Neurology, Department of Neuroscience,University of Sheffield, Sheffield, UK[15]Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany[16]Department of Psychiatry, Universityof Dublin, Trinity College, Dublin, Ireland[17]Psychiatric Brain and Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena,Germany[18]Department of Psychology, Stanford University, Stanford, CA, USA[19]Section for Experimental Psychopathology and Neuroimaging, Department of GeneralPsychiatry, Heidelberg University Hospital, Heidelberg, Germany[20]Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea[21]Neuroimaging Sciences,University of Edinburgh, Edinburgh, UK[22]Scottish Imaging Network–A Platform for Scientific Excellence (SINAPSE), Giffnock, UK[23]Centre for Clinical Brain Sciences, University ofEdinburgh, Edinburgh, UK[24]Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK[25]Department ofPsychological and Brain Sciences, Dartmouth College, Hanover, NH, USA[26]Department of Psychology, Dutch Autism and ADHD Research Center, Brain and Cognition, Universityof Amsterdam, Amsterdam, The Netherlands[27]CADE Clinic, Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia[28]Division of Psychiatry,University of Edinburgh, Edinburgh, UK[29]Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, NationalInstitutes of Health, Bethesda, MD, USA[30]Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK[31]Department ofPsychiatry, University of Cambridge, Cambridge, UK[32]Department of Neuroscience, Medical School, University of Sheffield, Sheffield, UK[33]Department of Psychiatry, Universityof Pittsburgh, School of Medicine, Pittsburgh, PA[34]Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick, NSW, Australia[35]Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia[36]Janssen Research and Development, Titusville, NJ, USA[37]Department of Psychiatryand Behavioral Sciences, Center of Excellence on Mood Disorders, Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA[38]The PatrickWild Centre, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK[39]NeuroImaging Center, University Medical Center Groningen, University of Groningen,Groningen, The Netherlands[40]Department of Psychiatry, Leiden University Medical Center, Leiden University, Leiden, The Netherlands[41]Leiden Institute for Brain and Cognition,Leiden, The Netherlands[42]Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands[43]School of Psychology, University of East London, London,UK.
Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.
基金：
National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London; Academy of Medical SciencesAcademy of Medical Sciences (AMS) [AMS-SGCL8]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA; MRC CDA Fellowship [MR/J008915/1]; VENI grant (NWO grant) [016.156.077]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01MH1000, 1 P50 MH106435, R01 MH073953, R01 MH060952]; Trinity College School of Medicine; Instituto de Salud Carlos III - Subdireccion General de EvaluacionInstituto de Salud Carlos III; European Regional Development FundEuropean Union (EU) [CP14/00041, PI14/00292]
第一作者机构：[1]Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK[*1]Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, King’s College London, 103 Denmark Hill, London SE5 8AF, UK,
通讯作者：
通讯机构：[*1]Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, King’s College London, 103 Denmark Hill, London SE5 8AF, UK,
推荐引用方式(GB/T 7714)：
T Wise,J Radua,E Via,et al.Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis[J].MOLECULAR PSYCHIATRY.2017,22(10):1455-1463.doi:10.1038/mp.2016.72.
APA：
T Wise,J Radua,E Via,N Cardoner,O Abe...&D Arnone.(2017).Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis.MOLECULAR PSYCHIATRY,22,(10)
MLA：
T Wise,et al."Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis".MOLECULAR PSYCHIATRY 22..10(2017):1455-1463
医学