机构：[1]Department of Reproductive Medicine, the First Affiliated Hospital of Dali University, Dali, People’s Republic of China[2]Clinical Medicine College of Dali University, Dali, People’s Republic of China[3]Department of Reproductive and Genetic, the First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China医技科室医学影像中心CT室昆明医科大学附属第一医院[4]Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dali University, Dali, People’s Republic of China
Male infertility is a common human reproductive defect that can be resulted from spermatogenesis impairment. DMRT1 encodes a male-specific transcriptional regulator and is important for human spermatogenesis. This study was designed to explore the relationship between the Single Nucleotide Polymorphism (SNP) of DMRT1 and oligospermia. Two SNPs namely rs3739583 and rs4742608, were screened in 212 infertile men with oligospermia and 217 normal controls by using a PCR-RFLP assay. The genotyping data showed that the frequencies of allele A (64.9% vs. 57.8%, p=0.041, OR=1.346, 95% CI 1.021 +/- 1.773) and genotype AA (39.1% vs. 29.0%, p=0.027, OR=1.604, 95% CI 1.073 +/- 2.398) of SNP rs4742608 were significantly higher in the infertile patients with oligospermia compared with the normal controls. Our data suggest that the SNP rs4742608 in DMRT1 is associated with oligospermia and may affect the genetic susceptibility to human oligospermia.
基金：
Doctoral Degree Activation Fund for Scientific Research Projects of Dali University [KYBS201612]; Research topic for Dali Bai Autonomous Prefecture Committee of Jiusan Society [16DJ04]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81300542, 81560458, 31601155]
第一作者机构：[1]Department of Reproductive Medicine, the First Affiliated Hospital of Dali University, Dali, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[3]Department of Reproductive and Genetic, the First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China[4]Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dali University, Dali, People’s Republic of China[*1]Department of Reproductive and Genetic The First Affiliated Hospital of Kunming Medical University Kunming People’s Republic of China[*2]Department of Biochemistry and Molecular Biology College of Basic Medical Sciences Dali University Dali People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhang Ruo-Peng,He Pei,Chai Bei-Bei,et al.The single nucleotide polymorphism of DMRT1 is associated with oligospermia[J].BIOMEDICAL RESEARCH-INDIA.2017,28(16):7172-7176.
APA：
Zhang, Ruo-Peng,He, Pei,Chai, Bei-Bei,Li, Zheng-Wei,Xu, Yi-Juan...&Xiong, Wei.(2017).The single nucleotide polymorphism of DMRT1 is associated with oligospermia.BIOMEDICAL RESEARCH-INDIA,28,(16)
MLA：
Zhang, Ruo-Peng,et al."The single nucleotide polymorphism of DMRT1 is associated with oligospermia".BIOMEDICAL RESEARCH-INDIA 28..16(2017):7172-7176
