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The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicentre randomized controlled trial (VENIM)

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收录情况： ◇ SCIE

作者：
Tao Wang[1] ; Gang Liu[2] ; Kun He[3] ; Xin Lu[1] ; Xianquan Liang[4] ; Meng Wang[5] ; Rong Zhu[6] ; Zongru Li[1] ; Feng Chen[7] ; Jun Ke[7] ; Qingming Lin[7] ; Chuanyun Qian[8] ; Bo Li[8] ; Jie Wei[9] ; Jingjun Lv[9] ; Li Li[10] ; Yanxia Gao[10] ; Guofeng Wu[11] ; Xiaohong Yu[11] ; Weiqin Wei[11] ; Ying Deng[12] ; Fengping Wang[12] ; Hong Zhang[13] ; Yun Zheng[13] ; Hong Zhan[14] ; Jinli Liao[14] ; Yingping Tian[15] ; Dongqi Yao[15] ; Jingsong Zhang[16] ; Xufeng Chen[16] ; Lishan Yang[17] ; Jiali Wu[17] ; Yanfen Chai[18] ; Songtao Shou[18] ; Muming Yu[18] ; Xudong Xiang[19] ; Dongshan Zhang[19] ; Fengying Chen[20] ; Xiufeng Xie[20] ; Yong Li[21] ; Bo Wang[21] ; Wenzhong Zhang[22] ; Yongli Miao[22] ; Michael Eddleston[23] ; Jianqiang He[1] ; Yong Ma[1] ; Shengyong Xu[1] ; Yi Li[1] ; Huadong Zhu[1] ; Xuezhong Yu[1] ;
机构： [1]Emergency Department, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, China [2]Department ofOrthopedics, Peking Union Medical College Hospital, Beijing, China [3]Department of Gastroenterology, Peking Union Medical College Hospital,Beijing, China [4]Emergency Department, Guiyang Second People Hospital,Guiyang, China [5]Department of Science and Technology, Beijing TiantanHospital, Capital Medical University, Beijing 100050, China [6]Department ofUltrasound, Peking Union Medical College Hospital, Beijing, China [7]Department of Emergency, Fujian Provincial Hospital, Provincial ClinicalMedical College of Fujian Medical University, Fuzhou, China [8]EmergencyDepartment, First Affiliated Hospital of Kunming Medical University, Kunming,China [9]Department of Emergency, Renmin Hospital of Wuhan University,Wuhan, China [10]Emergency Department, First Affiliated Hospital ofZhengzhou University, Zhengzhou, China [11]Emergency Department,Affiliated Hospital of Guizhou Medical University, Guiyang, China [12]Department of Emergency, The Second Affiliated Hospital of HarbinMedical University, Harbin, China [13]Department of Emergency, The FirstAffiliated Hospital of Anhui Medical University, Hefei, China [14]Department ofEmergency Medicine, The First Affiliated Hospital of SUN Yat-sen University,Guangzhou, China [15]Emergency Department, Second Hospital of HebeiMedical University, Shijiazhuang, China [16]Department of Emergency, Firstaffiliated hospital of Nanjing Medical University, Nanjing, China [17]Department of Emergency, General Hospital of Ningxia Medical University,Yinchuan, China [18]Emergency Department, Tianjin Medical UniversityGeneral Hospital, Tianjin, China [19]Department of Emergency Medicine,Second Xiangya Hospital, Institute of Emergency Medicine and DifficultDiseases, Central South University, Changsha, China [20]Department ofEmergency, The Affiliated Hospital of Inner Mongolia Medical University,Hohhot, China [21]Department of Emergency, Cangzhou City Center Hospital,Cangzhou, China [22]Department of Emergency, First Hospital of Handan City,Handan, China [23]Pharmacology, Toxicology and Therapeutics, Centre forCardiovascular Science, University of Edinburgh, Edinburgh, UK
出处：
DOI： 10.1186/s12890-017-0467-6
ISSN：

关键词： Ventilation strategy Noninvasive mechanical ventilation Invasive mechanical ventilation Acute respiratory failure Immunocompromised patients

摘要：
Background: Acute respiratory failure (ARF) is still one of the most severe complications in immunocompromised patients. Our previous systematic review showed noninvasive mechanical ventilation (NIV) reduced mortality, length of hospitalization and ICU stay in AIDS/hematological malignancy patients with relatively less severe ARF, compared to invasive mechanical ventilation (IMV). However, this systematic review was based on 13 observational studies and the quality of evidence was low to moderate. The efficacy of NIV in more severe ARF and in patients with other causes of immunodeficiency is still unclear. We aim to determine the efficacy of the initial ventilation strategy in managing ARF in immunocompromised patients stratified by different disease severity and causes of immunodeficiency, and explore predictors for failure of NIV. Methods and analysis: The VENIM is a multicentre randomized controlled trial (RCT) comparing the effects of NIV compared with IMV in adult immunocompromised patients with severe hypoxemic ARF. Patients who meet the indications for both forms of ventilatory support will be included. Primary outcome will be 30-day all-cause mortality. Secondary outcomes will include in-hospital mortality, length of stay in hospital, improvement of oxygenation, nosocomial infections, seven-day organ failure, adverse events of intervention, et al. Subgroups with different disease severity and causes of immunodeficiency will also be analyzed. Discussion: VENIM is the first randomized controlled trial aiming at assessing the efficacy of initial ventilation strategy in treating moderate and severe acute respiratory failure in immunocompromised patients. The result of this RCT may help doctors with their ventilation decisions.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81550034]; National Key Clinical Specialty Construction Program [20111204]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 4 区 呼吸系统
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 呼吸系统
JCR分区：
出版当年[2017]版：
Q2 RESPIRATORY SYSTEM
最新[2023]版：
Q2 RESPIRATORY SYSTEM

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Emergency Department, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, China
共同第一作者：
推荐引用方式(GB/T 7714)：
Tao Wang,Gang Liu,Kun He,et al.The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicentre randomized controlled trial (VENIM)[J].BMC PULMONARY MEDICINE.2017,17:doi:10.1186/s12890-017-0467-6.
APA：
Tao Wang,Gang Liu,Kun He,Xin Lu,Xianquan Liang...&Xuezhong Yu.(2017).The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicentre randomized controlled trial (VENIM).BMC PULMONARY MEDICINE,17,
MLA：
Tao Wang,et al."The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicentre randomized controlled trial (VENIM)".BMC PULMONARY MEDICINE 17.(2017)

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