机构：[1]Department of Physiology, Kunming Medical University,1168 West Chunrong Road, Yuhua Avenue, Chenggong,Kunming 650500, Yunnan, China[2]Department of Dermatology, The First Affiliated Hospital ofKunming Medical University, Kunming, China内科科室皮肤科昆明医科大学附属第一医院[3]Department of Gastroenterology, The Second AffiliatedHospital of Kunming Medical University, Kunming, China
Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix. However, the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-21 may play pivotal roles in the regulation of a variety of skin fibrosis, including keloid, scleroderma, and hypertrophic scar. In this review, we outline the structure, expression, and regulation of microRNA-21 and its role in fibrotic skin diseases. In future, it may be useful as a prognostic or diagnostic marker. However, there is a significant amount of work required to increase our current understanding of the role of microRNA-21 in skin fibrosis.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81560502]; Science and Technology Leading Talent Project of Yunnan Province [2017HA010]; National Natural Science Foundation of Yunnan Province [2016FB044, 2014FB008]; Health Science and Technology Project of Yunnan Province [2016NS005]; Education Department Fund of Yunnan Province [2014Y165, 2015Z082]; Kunming Medical University
第一作者机构：[1]Department of Physiology, Kunming Medical University,1168 West Chunrong Road, Yuhua Avenue, Chenggong,Kunming 650500, Yunnan, China[2]Department of Dermatology, The First Affiliated Hospital ofKunming Medical University, Kunming, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Yan,Zhang Juan,Lei Yuying,et al.MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment[J].MOLECULAR DIAGNOSIS & THERAPY.2017,21(6):633-642.doi:10.1007/s40291-017-0294-8.
APA：
Li, Yan,Zhang, Juan,Lei, Yuying,Lyu, Lechun,Zuo, Ruiling&Chen, Ting.(2017).MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment.MOLECULAR DIAGNOSIS & THERAPY,21,(6)
MLA：
Li, Yan,et al."MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment".MOLECULAR DIAGNOSIS & THERAPY 21..6(2017):633-642
