机构：[1]Department of Pediatrics, Children’s Hospital of Fudan University, and the Laboratory of Neonatal Medicine of National Health and Family Planning Commission, Shanghai, China[2]Department of Pediatrics, Tibet Autonomous Regional People’s Hospital, Lhasa, Tibet, China[3]Department of Pediatrics, First General Hospital of Kunming Medical University, Kunming, Yunnan, China[4]Department of Pediatrics, Huai’an Women and Children’s Hospital, Huai’an, Jiangsu, China内科科室儿科昆明医科大学附属第一医院
AimThis Chinese study assessed partial pressure of exhaled nitric oxide (PeNO) in healthy Tibetan and non-Tibetan newborn infants born at a very high altitude. MethodsFull-term Tibetan and non-Tibetan neonates born in Lhasa, 3658 metres above sea level, were compared to non-Tibetan neonates born in Kunming (1891 m) and Huai'an (16 m). The chemiluminiscence technique was used to measure the fraction of exhaled nitric oxide during spontaneous tidal breathing and this was then converted to partial pressure of exhaled nitric oxide (PeNO). ResultsIn their first week, Tibetan and non-Tibetan neonates born in Lhasa had persistently higher PeNO levels than non-Tibetan neonates born in Kunming and Huai'an, which was further verified by partial pressure of inspired oxygen adjustment. However, the non-Tibetans born in Lhasa required short-term oxygen therapy to improve their early postnatal oxygenation. The temporal changes of PeNO and cardio-respiratory function measurements demonstrated that Tibetan and non-Tibetan newborns in Lhasa initially needed to adapt to attain homoeostasis in oxygenation and gas exchange. ConclusionTibetan and non-Tibetan newborn infants living at the same high altitude demonstrated comparable PeNO levels during postnatal adaptation to hypobaric hypoxia, which warrants further investigation of the mechanism of endogenous nitric oxide and hypoxic tolerance.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30872801]; 211 Project (Phase III) of the Ministry of Education; Shanghai Municipal Health and Family Planning Commission [LJ 06038]
第一作者机构：[1]Department of Pediatrics, Children’s Hospital of Fudan University, and the Laboratory of Neonatal Medicine of National Health and Family Planning Commission, Shanghai, China
通讯作者：
通讯机构：[*1]Departments of Pediatrics and Neonatology, Children’s Hospital of Fudan University, 399 Wanyuan Road, Shanghai 201102, China.
推荐引用方式(GB/T 7714)：
Wu Panpan,Shanminna,Liang Kun,et al.Exhaled nitric oxide is associated with postnatal adaptation to hypoxia in Tibetan and non-Tibetan newborn infants[J].ACTA PAEDIATRICA.2016,105(5):475-482.doi:10.1111/apa.13331.
APA：
Wu, Panpan,Shanminna,Liang, Kun,Yue, Hongni,Qian, Liling&Sun, Bo.(2016).Exhaled nitric oxide is associated with postnatal adaptation to hypoxia in Tibetan and non-Tibetan newborn infants.ACTA PAEDIATRICA,105,(5)
MLA：
Wu, Panpan,et al."Exhaled nitric oxide is associated with postnatal adaptation to hypoxia in Tibetan and non-Tibetan newborn infants".ACTA PAEDIATRICA 105..5(2016):475-482
