Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program
机构：[1]Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, China[2]Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China内科系统(本部)感染科（本部）北京朝阳医院[3]Department of Clinical Laboratory,The First Affiliated Hospital of Kunming Medical University,Kunming,China昆明医科大学附属第一医院医技科室医学检验科[4]Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[5]Department of Clinical Laboratory, Beijing Hospital, Beijing, China[6]Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China[7]Department of Clinical Laboratory, The First Teaching Hospital of Xinjiang Medical University, Urumqi, China[8]Department of Clinical Laboratory, Southwest Hospital, Chongqing, China[9]Department of Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang, China中国医科大学盛京医院[10]Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China[11]Department of Clinical Laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin, China[12]Department of Clinical Laboratory, Peking Union Medical College Hospital, Beijing, China[13]Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China[14]Department of Clinical Laboratory, Xijing Hospital, Xi’an, China[15]Department of Clinical Laboratory, China-Japan Union Hospital of Jilin University, Jilin, China医技系统检验科吉林大学中日联谊医院[16]Department of Clinical Laboratory, The First Affiliated Hospital, Zhejiang University, Hangzhou, China医技科室医学检验科浙江大学医学院附属第一医院[17]Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China[18]Department of Clinical Laboratory, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China[19]Department of Infectious Diseases, Guangzhou Institute of Respiratory Disease, Guangzhou, China
This study investigated the antimicrobial susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolates causing adult community-acquired respiratory tract infections (CARTIs) in China. A multicentre resistance surveillance study (CARTIPS) investigating 1046 clinical isolates from 19 hospitals in China was conducted from 2013 to 2014. Based on the minimum inhibitory concentration (MIC) breakpoints of oral penicillin, the percentages of penicillin-resistant, penicillin-intermediate and penicillin-susceptible S. pneumoniae were 44.1%, 13.7%, and 42.2%, respectively. The rates of penicillin-non-susceptible S. pneumoniae ranged from 27.9% to 72.2% in different cities, with the highest rate in Nanchang. Macrolides, including azithromycin, clarithromycin and erythromycin, showed the lowest activities against S. pneumoniae isolates, with resistance rates of 90.5%, 92.2% and 93.0%, respectively. However, 98% of these strains were susceptible to levofloxacin and moxifloxacin. For H. influenzae isolates, most of the antimicrobials agents exhibited good activities. However, ampicillin and trimethoprim/sulfamethoxazole showed relatively lower activity against H. influenzae, with resistance rates of 35.0% and 54.4%, respectively. beta-lactamase production rates amongst H. influenzae and M. catarrhalis were 31.0% and 87.1%, respectively. In addition, a total of 15 beta-lactamase-negative ampicillin-resistant (BLNAR) strains identified in this study were resistant to ampicillin, amoxicillin/clavulanic acid, cefaclor and cefuroxime. Most of the antimicrobial agents showed excellent activity against M. catarrhalis, with susceptibility rates of > 90%. The results from the current study confirmed the regional variations in antimicrobial susceptibility of major CARTI pathogens and provided some choices for the treatment of these organisms. Continuous national surveillance of the epidemiology of CARTIs is strongly warranted in China. (C) 2016 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
第一作者机构：[1]Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, China
通讯作者：
通讯机构：[1]Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, China[*1]Department of Clinical Laboratory, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China.
推荐引用方式(GB/T 7714)：
Zhang Yawei,Zhang Feifei,Wang Hui,et al.Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program[J].JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE.2016,5:36-41.doi:10.1016/j.jgar.2016.03.002.
APA：
Zhang, Yawei,Zhang, Feifei,Wang, Hui,Zhao, Chunjiang,Wang, Zhanwei...&Zhuo, Chao.(2016).Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program.JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE,5,
MLA：
Zhang, Yawei,et al."Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program".JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE 5.(2016):36-41
