机构：[1]Department of Ophthalmology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China[2]Department of Rheumatology and Immunology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China[3]Department of Ophthalmology, the Second People’s Hospital of Zhengzhou City, Zhengzhou, Henan Province, China[4]Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China外科科室眼科昆明医科大学附属第一医院
Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (INK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore a possible mechanism of action of JNK signaling pathway in glaucoma-induced retinal optic nerve damage. We established a mouse model of chronic ocular hypertension by reducing the aqueous humor followed by photocoagulation using the laser ignition method. Results showed significant pathological changes in the ocular tissues after the injury. Apoptosis of retinal ganglion cells increased with increased intraocular pressure, as did JNK3 mRNA expression in the retina. These data indicated that the increased expression of JNK3 mRNA was strongly associated with the increase in intraocular pressure in the retina, and correlated positively with the apoptosis of retinal ganglion cells.
基金：
This work was supported by grants from the Youth Foundation of Luzhou Medical College
of Luzhou City of Sichuan Province of China, No. [2010]108; the Talent Fund of the Affiliated Hospital
of Luzhou Medical College of Luzhou City of Sichuan Province of China, No. [2011]43.
第一作者机构：[1]Department of Ophthalmology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yue He,Jie Chen,Shu-guang Zhang,et al.c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis[J].NEURAL REGENERATION RESEARCH.2015,10(3):432-437.doi:10.4103/1673-5374.153692.
APA：
Yue He,Jie Chen,Shu-guang Zhang,Yuan-sheng Yuan,Yan Li...&Jin-hua Gan.(2015).c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis.NEURAL REGENERATION RESEARCH,10,(3)
MLA：
Yue He,et al."c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis".NEURAL REGENERATION RESEARCH 10..3(2015):432-437
