机构：[1]Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China,[2]Department of Emergency Medicine and Medical ICU, The First Affiliated Hospital of Kunming Medical University, Kunming, China,内科科室外科科室干疗科急诊医学科3号楼重症监护病房（ICU）重症医学科昆明医科大学附属第一医院[3]Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China,内科科室外科科室急诊医学科重症医学科[4]Department of Critical Care Medicine, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China,内科科室外科科室干疗科3号楼重症监护病房（ICU）重症医学科[5]Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China,四川大学华西医院[6]Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China,[7]Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China,四川大学华西医院[8]Department of Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China,首都医科大学附属同仁医院[9]Department of Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China,[10]Department of Critical Care Medicine, Peking University People’s Hospital, Beijing, China, 11 Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China,首都医科大学附属同仁医院[11]Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China[12]Department of Critical Care Medicine, Zhejiang Provincial People’s Hospital, Hangzhou, China,[13]Department of Critical Care Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China,华中科技大学同济医学院附属同济医院[14]Department of Critical Care Medicine, Hebei Medical University Fourth Hospital, Shijiazhuang, China,河北医科大学第四医院[15]Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, China,[16]Department of Emergency and Intensive Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China,华中科技大学同济医学院附属同济医院重庆医科大学附属第一医院[17]Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, Beijing, China,河北医科大学第四医院[18]Department of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China,[19]Emergency ICU, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China,外科系统急诊医学科重症医学科重庆医科大学附属第一医院[20]Department of Critical Care Medicine, Guangdong General Hospital, Guangzhou, China,广东省人民医院[21]Department of Critical Care Medicine, Hainan Provincial People’s Hospital, Haikou, China,[22]Department of Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China
Introduction: Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology and outcome of severe sepsis and septic shock in mixed ICU in mainland China, as well as the independent predictors of mortality. Methods: We performed a 2-month prospective, observational cohort study in 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during the study period were screened and patients with severe sepsis or septic shock were included. Results: A total of 484 patients, 37.3 per 100 ICU admissions were diagnosed with severe sepsis (n = 365) or septic shock (n = 119) according to clinical criteria and included into this study. The most frequent sites of infection were the lung and abdomen. The overall ICU and hospital mortality rates were 28.7% (n = 139) and 33.5% (n = 162), respectively. In multivariate analyses, APACHE II score (odds ratio[OR], 1.068; 95% confidential interval[CI], 1.027-1.109), presence of ARDS (OR, 2.676; 95% CI, 1.691-4.235), bloodstream infection (OR, 2.520; 95% CI, 1.142-5.564) and comorbidity of cancer (OR, 2.246; 95% CI, 1.141-4.420) were significantly associated with mortality. Conclusions: Our results indicated that severe sepsis and septic shock were common complications in ICU patients and with high mortality in China, and can be of help to know more about severe sepsis and septic shock in China and to improve characterization and risk stratification in these patients.
基金：
Capital Clinical Application Research grant from the Science and Technology Commission of Beijing [Z131107002213112]
第一作者机构：[1]Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Jianfang Zhou,Chuanyun Qian,Mingyan Zhao,et al.Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China[J].PLOS ONE.2014,9(9):doi:10.1371/journal.pone.0107181.
APA：
Jianfang Zhou,Chuanyun Qian,Mingyan Zhao,Xiangyou Yu,Yan Kang...&Bin Du.(2014).Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China.PLOS ONE,9,(9)
MLA：
Jianfang Zhou,et al."Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China".PLOS ONE 9..9(2014)
