机构：[1]State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, Shandong Province, China,[2]Public Health College of Wuhan University, Wuhan, Hubei Province, China,[3]Zhongshan Ophthalmic Center of Sun Yat-sen University, Guangzhou, Guandong Province, China,[4]Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China,[5]Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China,外科科室眼科昆明医科大学附属第一医院[6]Eye Center, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China,四川大学华西医院[7]Department of Ophthalmology, First clinical College of Harbin Medical University, Harbin, Heilongjiang Province, China,[8]Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China,[9]Beijing Institute of Ophthalmology, Beijing, China,首都医科大学附属同仁医院[10]The People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, China,[11]Qinghai University Affiliated Hospital, Xining, China[12]Department of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei Province, China
Objective: To understand the prevalence and demographic characteristics of infectious keratitis and infectious corneal blindness. Methods: A multi-center, population-based cross-sectional study was conducted from January 1 to August 31, 2010. A total of 191,242 individuals of all age groups from 10 geographically representative provinces were sampled using stratified, multi-stage, random and systematic sampling procedures. A majority, 168,673 (88.2%), of those sampled participated in the study. The examination protocol included a structured interview, visual acuity testing, an external eye examination, and an anterior segment examination using a slit lamp. The causes and sequelae of corneal disease were identified using uniform customized protocols. Blindness in one eye caused by infectious keratitis was defined as infectious corneal blindness. Results: The prevalence of past and active infectious keratitis was 0.192% (95% confidence interval [CI], 0.171-0.213%), and the prevalence of viral, bacterial, and fungal keratitis was 0.11%, 0.075%, and 0.007%, respectively. There were 138 cases of infectious corneal blindness in at least one eye in the study population (prevalence of 0.082% [95% CI, 0.068%-0.095%]). Statistical analysis suggested that ocular trauma, alcoholic consumption, low socioeconomic levels, advanced age, and poor education were risk factors for infectious corneal blindness. Conclusions: Infectious keratitis is the leading cause of corneal blindness in China. Eye care strategies should focus on the prevention and rehabilitation of infectious corneal blindness.
基金：
Consultation Program of Chinese Academy of
Engineering (No. 2009-77).
第一作者机构：[1]State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, Shandong Province, China,[12]Department of Ophthalmology, the Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei Province, China
通讯作者：
推荐引用方式(GB/T 7714)：
Song Xiusheng,Xie Lixin,Tan Xiaodong,et al.A Multi-Center, Cross-Sectional Study on the Burden of Infectious Keratitis in China[J].PLOS ONE.2014,9(12):doi:10.1371/journal.pone.0113843.
APA：
Song, Xiusheng,Xie, Lixin,Tan, Xiaodong,Wang, Zhichong,Yang, Yanning...&Wang, Qing.(2014).A Multi-Center, Cross-Sectional Study on the Burden of Infectious Keratitis in China.PLOS ONE,9,(12)
MLA：
Song, Xiusheng,et al."A Multi-Center, Cross-Sectional Study on the Burden of Infectious Keratitis in China".PLOS ONE 9..12(2014)
