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Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells

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收录情况： ◇ SCIE

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机构： [1]Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Institute of Urology, Kunming 650101 [2]The First Affiliated Hospital of Kunming Medical University, Kunming 650031, P.R. China

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关键词： bladder carcinoma membrane toxin 12 CXCR4 proliferation invasiveness

摘要：

We investigated the effect of membrane toxin 12 (MT-12), isolated from Naja naja atra, a species of Chinese Cobra, on the proliferation and invasion of human bladder cancer EJ cells and studied its mechanisms using MTT assay, Transwell chamber invasion assay, scanning electron microscopy and flow cytometry. The results indicated that MT-12 inhibited the proliferation of bladder cancer cells in a dose-dependent manner. The half maximal inhibitory concentration (IC50) after 72 h was 0.66 mu g/ml. The invasion of cells decreased with increasing doses of MT-12 (0.125-0.5 mu g/ml, P<0.001). Expression of CXCR4 decreased with the effect of MT-12 for a particular concentration range (0.125-0.5 mu g/ml). To conclude, MT-12 is capable of inhibiting the proliferation and invasion of bladder cancer EJ cells. This mechanism may be associated with reduced expression of CXCR4 protein.

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出版当年[2013]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

JCR分区：

出版当年[2012]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY

最新[2023]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 ONCOLOGY

影响因子： 3.4 最新[2023版] 3 最新五年平均 1.17 出版当年[2012版] 0.96 出版当年五年平均 0.418 出版前一年[2011版] 1.484 出版后一年[2013版]

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第一作者机构： [1]Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Institute of Urology, Kunming 650101

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通讯作者：

通讯机构： [*1]Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Institute of Urology, Kunming 650101, P.R. China

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