机构：[1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China[2]Department of Dermatology, The First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan, China内科科室皮肤科昆明医科大学附属第一医院[3]Yuxi City Center for Disease Control and Prevention, Yuxi 653100, Yunnan, China云南省第一人民医院[4]School of Life Science, Liaoning Normal University, Dalian 116081, Liaoning, China[5]Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
Leprosy is an ancient infectious disease, with over 200,000 affected people (mainly in Asia and Africa) being registered annually. Genetic factors may confer susceptibility to this disease. In the present study, we genotyped 12 genetic variants of the MRC1 gene and the IFNG gene in 527 Han Chinese with leprosy and 583 healthy individuals from Yunnan, China, to discern potential association of these two genes with leprosy. In particular, we aimed to validate the recently reported association of MRC1 variant rs1926736 (p.G396S) and IFNG variant rs2430561 (+874 T > A) with leprosy, which were initially observed in Vietnamese and Brazilian populations, respectively. Our results failed to confirm the reported association between variants rs1926736 and rs2430561 and leprosy in Han Chinese. However, we found that variants rs692527 (P = 0.022) and rs34856358 (P = 0.022) of the MRC1 gene were associated with paucibacillary leprosy, and rs3138557 of the IFNG gene was significantly associated with multibacillary leprosy. The exact role of the MRC1 gene and the IFNG gene in leprosy awaits future study.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30925021]; Yunnan Province [2009CI119]; Chinese Academy of SciencesChinese Academy of Sciences
第一作者机构：[1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China[5]Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Wang Dong,Feng Jia-Qi,Li Yu-Ye,et al.Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China[J].HUMAN GENETICS.2012,131(7):1251-1260.doi:10.1007/s00439-012-1153-7.
APA：
Wang, Dong,Feng, Jia-Qi,Li, Yu-Ye,Zhang, Deng-Feng,Li, Xiao-An...&Yao, Yong-Gang.(2012).Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China.HUMAN GENETICS,131,(7)
MLA：
Wang, Dong,et al."Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China".HUMAN GENETICS 131..7(2012):1251-1260
