机构：[1]The First Affiliated Hospital of Kunming Medical College, Kunming, China昆明医科大学附属第一医院[2]Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China[3]Graduate School of the Chinese Academy of Sciences, Beijing, China
Dendritic cells (DCs) play a pivotal role in host defense against invaded pathogens including fungi, while DCs are targeted by fungi for deleterious regulation of the host immune response. A few studies have reported fungal modulation of DC function in these immunocompromised AIDS patients. Cryptococcus neoformans (C. neoformans) is referred as one of the opportunistic fungi of AIDS. Here, we isolated native C. neoformans from an AIDS patient and investigated its effects on DC activation and function. Stimulation of C. neoformans matured DCs, and enhanced DC-mediated HIV-1 trans-infection; moreover, C. neoformans-stimulated DCs promoted the activation of resting T cells and provided more susceptible targets for HIV-1 infection. Microbial translocation has been proposed as the cause of systemic immune activation in chronic HIV-1 infection. Understanding the potential effects of pathogens on HIV-1-DC interactions could help elucidate viral pathogenesis and provide a new insight for against the spread of HIV. (C) 2012 Elsevier Inc. All rights reserved.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China [81171567]; Chinese Academy of SciencesChinese Academy of Sciences [KSCX2-KW-BR-1]; Shanghai Rising-Star Program (A type) [11QA1407700]
第一作者机构：[2]Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China[3]Graduate School of the Chinese Academy of Sciences, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Heifei Road, No. 411, Shanghai 200025, China.
推荐引用方式(GB/T 7714)：
Qin Yan,Li Yu-Ye,Jiang Ai-ping,et al.Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2012,423(4):709-714.doi:10.1016/j.bbrc.2012.06.020.
APA：
Qin, Yan,Li, Yu-Ye,Jiang, Ai-ping,Jiang, Jin-Feng&Wang, Jian-Hua.(2012).Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,423,(4)
MLA：
Qin, Yan,et al."Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 423..4(2012):709-714
