机构：[1]State Key Laboratory of Oral Diseases, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, People’s Republic of China[2]Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, People’s Republic of China[3]Department of Stomatology Institute, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650032, China昆明医科大学附属第一医院云南省第一人民医院
It is widely accepted that tumor-induced lymphangiogenesis driven by vascular endothelial growth factor (VEGF)-C- and/or VEGF-D-induced activation of VEGF receptor (VEGFR)-3 could promote lymphatic metastasis. In this study, tumor growth and intratumoral expression level of VEGF-C and -D following administration of local hyperthermia was evaluated in nude mice model of tongue squamous cell carcinoma (SCC). The data demonstrated that the size of tumor in local hyperthermia was 26.5% of control group, and that local hyperthermia markedly suppressed the mRNA and protein expression of VEGF-C and -D as determined by quantitative real-time RT-PCR, Western blot and immunohistochemistry (P < 0.05). These results suggest that, accompanying with tumor growth inhibition, local hyperthermia may act as an anti-lymphangiogenic role by suppressing the expression of tumor VEGF-C and -D, and thereby inhibiting cancer cell lymphatic metastasis in tongue SCC. (C) 2009 Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30300391, 30872889]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education MinistryScientific Research Foundation for the Returned Overseas Chinese Scholars [20098-8-2]
第一作者机构：[1]State Key Laboratory of Oral Diseases, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, People’s Republic of China[2]Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, People’s Republic of China[*1]Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, People’s Republic of China
通讯作者：
通讯机构：[*1]Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, People’s Republic of China
推荐引用方式(GB/T 7714)：
Liang Xinhua,Zhou Hao,Liu Xian,et al.Effect of local hyperthermia on lymphangiogenic factors VEGF-C and -D in a nude mouse xenograft model of tongue squamous cell carcinoma[J].ORAL ONCOLOGY.2010,46(2):111-115.doi:10.1016/j.oraloncology.2009.12.001.
APA：
Liang, Xinhua,Zhou, Hao,Liu, Xian,He, Yongwen,Tang, Yaling...&Yang, Jing.(2010).Effect of local hyperthermia on lymphangiogenic factors VEGF-C and -D in a nude mouse xenograft model of tongue squamous cell carcinoma.ORAL ONCOLOGY,46,(2)
MLA：
Liang, Xinhua,et al."Effect of local hyperthermia on lymphangiogenic factors VEGF-C and -D in a nude mouse xenograft model of tongue squamous cell carcinoma".ORAL ONCOLOGY 46..2(2010):111-115
