机构：[1]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China内科科室精神科昆明医科大学附属第一医院[2]Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming, Yunnan, China[3]Magnetic Resonance Imaging Center, The First Hospital of Kunming City, Kunming, Yunnan, China[4]Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China[5]Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
To explore the possible abnormal resting-state activity in patients with obsessive-compulsive disorder (OCD), the regional homogeneity (ReHo) of 22 pairs of patients and well-matched healthy controls was calculated. Compared with controls, the patients showed higher ReHo in the left anterior cingulate cortex, but lower ReHo in the left inferior temporal gyrus. These findings supported the abnormal resting-state brain activity in drug-naive OCD patients. No significant correlations between ReHo value and four clinical characteristics were found, suggesting that abnormal ReHo might be trait-related in OCD. NeuroReport 21:786-790 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
基金：
United Funding of Yunnan Provincial Science and Technology Department and Kunming Medical College [2008C005R]; Funding of Yunnan Provincial Health Science and Technology Plan [2009 NS096, 2009NS092]
