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Expression of semaphorin 5A and its receptor plexin B3 contributes to invasion and metastasis of gastric carcinoma

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

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机构： [1]Department of Pathology, Xiangya Medical College, Central South University, Changsha 410008, Hunan Province, China [2]Department of Pathology, the first Affiliated Hospital of Kunming Medical College, Kunming 530032, Yunnan Province, China [3]Central Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou 570208, Hainan Province, China [4]Department of Basic Medicine, Huaihua Medical College, Huaihua 418000, Hunan Province, China

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关键词： Semaphorin 5A Plexin B3 Gastric carcinoma Invasion Metastasis

摘要：

AIM: To investigate the protein and mRNA expression of semaphorin 5A and its receptor plexin 133 in gastric carcinoma and explore its role in the invasion and metastasis of gastric carcinoma. METHODS: Expression of semaphorin 5A and its receptor plexin B3 in 48 samples of primary gastric carcinoma, its corresponding non-neoplastic mucosa, and matched regional lymph node metastasis was assayed by reverse transcription-polymerase chain reaction (RT-PCR), real-time RT-PCR and Western blotting. RESULTS: The protein and mRNA expression of semaphorin 5A and its receptor plexin B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma and lymph node metastasis (P < 0.05). Moreover, the expression of semaphorin 5A was closely correlated with that of plexin B3. CONCLUSION: Semaphorin 5A and its receptor plexin B3 play an important role in the invasion and metastasis of gastric carcinoma. (C) 2009 The WJG Press and Baishideng. All rights reserved.

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出版当年[2010]版：

大类 | 3 区医学

小类 | 4 区胃肠肝病学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区胃肠肝病学

JCR分区：

出版当年[2009]版：

Q3 GASTROENTEROLOGY & HEPATOLOGY

最新[2023]版：

Q1 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 4.3 最新[2023版] 5.1 最新五年平均 2.092 出版当年[2009版] 0 出版当年五年平均 2.081 出版前一年[2008版] 2.24 出版后一年[2010版]

第一作者：

第一作者机构： [1]Department of Pathology, Xiangya Medical College, Central South University, Changsha 410008, Hunan Province, China [2]Department of Pathology, the first Affiliated Hospital of Kunming Medical College, Kunming 530032, Yunnan Province, China

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通讯机构： [*1]Department of Pathology, Xiangya Medical College, Central South University, Changsha 410008, Hunan Province, China

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