机构：[1]Departments of Pediatrics, First Affiliated Hospital of Kunming Medical College, Kunming, China内科科室儿科昆明医科大学附属第一医院[2]Departments of Neurology, First Affiliated Hospital of Kunming Medical College, Kunming, China内科科室外科科室神经内科泌尿外科昆明医科大学附属第一医院[3]Department of Neurology, the Affiliated Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Mortality and neurologic deficits still. occurs frequently following bacterial meningitis in children, despite antibiotic treatment. We investigated the neuroprotective effects of brain-derived neurotrophic factor (BDNF) on brain neurons in bacterial meningitis. The rat model of bacterial meningitis and a normal rat model were developed. Either BDNF or albumin was injected into the cerebral ventricle 24 hours after and before inoculation for 7 days, respectively. Three of the rats treated with albumin died during the course of treatment, but none of those treated with BDNF. The neuronal population in both cerebral cortex and hippocampus of the rats treated with BDNF markedly increased, compared with the rats treated with albumin, but there was no significant difference between the rats treated with BDNF after and before inoculation, nor between the normal rats treated with BDNF and albumin. The present findings indicate that BDNF could protect a large number of neurons in cerebral cortex and hippocampus from inflammatory brain injury in bacterial meningitis. The administration of exogenous BDNF may be a new and effective way to decrease mortality and improve sequelae following bacterial meningitis. (C) 2007 by Elsevier Inc. All rights reserved.
基金：
The work of authors was supported by
Xilin Yu, BC, Prof., of the Laboratory Center, Hongfeng Tang BC, Prof.,
and Weizhong Gu BC, Technician, of Pathology, as well as Jianping Li
BC, Technician of Bacterial Laboratory in Affiliated Children’s Hospital,
Medical School, Zhejiang University, and was supported in part by funds
from Education Committee of Yunnan Province (No: 0112599).
第一作者机构：[1]Departments of Pediatrics, First Affiliated Hospital of Kunming Medical College, Kunming, China[*1]Pediatric Department,First Affiliated Hospital of Kunming Medical College, Kunming 650032,China.
通讯作者：
通讯机构：[*1]Pediatric Department,First Affiliated Hospital of Kunming Medical College, Kunming 650032,China.
推荐引用方式(GB/T 7714)：
Li Ling,Shui Quan-Xiang,Liang Kun,et al.Brain-derived neurotrophic factor rescues neurons from bacterial meningitis[J].PEDIATRIC NEUROLOGY.2007,36(5):324-329.doi:10.1016/j.pediatrneurol.2007.01.007.
