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The association between plasma HMGB1 and sRAGE and clinical outcome in intracerebral hemorrhage

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Chunyan Lei[1,2] * ; Jia Geng[1] ; Lianmei Zhong[1] ;
机构： [1]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Yunnan Province, China [2]Department of Neurology, First Affiliated Hospital of Kunming Medical University, No. 295 Xi Chang Lu, Kunming 650032, Yunnan Province, PR China
出处：
DOI： 10.1016/j.jneuroim.2020.577266
ISSN：

关键词： Clinical outcome HMGB1 Intracerebral hemorrhage sRAGE

摘要：
High-mobility group box 1 (HMGB1) and advanced glycation end-products (RAGE) are potential mediators of inflammation. We investigate the association between levels of HMGB1 and soluble RAGE (sRAGE) following intracerebral hemorrhage (ICH) and the severity of ICH. There was a significant trend towards higher poor functional outcome rate with increasing HMGB1 and sRAGE tercile. The correlation analysis indicated that the levels of HMGB1and sRAGE were positively correlated with hematoma volume. The receiver operating curve (ROC) was 0.718 for HMGB1 and 0.631 for sRAGE to poor functional outcome. HMGB1 and sRAGE quantification provides more accurate prognostic information after ICH. © 2020

基金：
This study was supported by a grant from the National Natural Science Foundation of China (grant no. 81701173 ) and Applied Basic Research Joint fund Project of Yunnan Province (grant no. 2018FE001(-141) ).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 3 区 神经科学 4 区 免疫学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 免疫学 4 区 神经科学
JCR分区：
出版当年[2020]版：
Q3 IMMUNOLOGY Q3 NEUROSCIENCES
最新[2023]版：
Q2 NEUROSCIENCES Q3 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Yunnan Province, China [2]Department of Neurology, First Affiliated Hospital of Kunming Medical University, No. 295 Xi Chang Lu, Kunming 650032, Yunnan Province, PR China
通讯作者：
通讯机构： [2]Department of Neurology, First Affiliated Hospital of Kunming Medical University, No. 295 Xi Chang Lu, Kunming 650032, Yunnan Province, PR China
推荐引用方式(GB/T 7714)：
Chunyan Lei,Jia Geng,Lianmei Zhong.The association between plasma HMGB1 and sRAGE and clinical outcome in intracerebral hemorrhage[J].JOURNAL OF NEUROIMMUNOLOGY.2020,345:doi:10.1016/j.jneuroim.2020.577266.
APA：
Chunyan Lei,Jia Geng&Lianmei Zhong.(2020).The association between plasma HMGB1 and sRAGE and clinical outcome in intracerebral hemorrhage.JOURNAL OF NEUROIMMUNOLOGY,345,
MLA：
Chunyan Lei,et al."The association between plasma HMGB1 and sRAGE and clinical outcome in intracerebral hemorrhage".JOURNAL OF NEUROIMMUNOLOGY 345.(2020)

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