机构：[a]Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China[b]Department of pathology, First Affiliated Hospital of Kunming Medical University, Yunnan Province, Kunming, China医技科室病理科昆明医科大学附属第一医院[c]Department of Organ Transplatation, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China昆明医科大学附属第一医院
BACKGROUND: This study aimed to summarize the association between diabetes mellitus (DM) and the incidence of lung cancer using a meta-analysis of cohort studies. MATERIALS AND METHODS: We systematically searched PubMed, Embase, and the Cochrane Library to identify potential cohort studies. Relative risk (RR) was used to calculate the association between DM and the risk of lung cancer. Subgroup analysis, sensitivity analysis, and test for publication bias were performed. Twenty cohort studies were selected. RESULTS: The participants with DM showed little or no significant effect on the risk of lung cancer (RR: 1.10; 95% CI: 0.99-1.23; P=0.087). DM was not associated with the risk of lung cancer in men (RR: 1.11; 95%CI: 0.92-1.35; P=0.270), but a significant association was observed in women (RR: 1.18; 95%CI: 1.10-1.28; P<0.001). Subgroup analysis suggested that smoker status were confounding variables that could bias the relationship between DM and the incidence of lung cancer. CONCLUSIONS: This meta-analysis suggests that DM has no significant impact on the incidence of lung cancer in men but has a harmful effect on women. This article is protected by copyright. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31960145, 31960426, 81460421, 81760455, 31960222, 31660246, 61660135, 81560037] Funding Source: Medline; Yunnan Province and Kunming Medical University of Applied Basic Research Joint Special Funds for Major Projects [2017FE468-003, 2018FE468(-001)] Funding Source: Medline
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区医学
小类|3 区医学：内科3 区医学：研究与实验
最新[2023]版：
大类|3 区医学
小类|3 区医学：内科3 区医学：研究与实验
JCR分区：
出版当年[2020]版：
Q1MEDICINE, GENERAL & INTERNALQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, GENERAL & INTERNALQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[a]Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China
推荐引用方式(GB/T 7714)：
Yi Z.-H,Agbana Y.L,Xiong G.-H,et al.Association between diabetes mellitus and lung cancer: meta-analysis(Open Access)[J].EUROPEAN JOURNAL OF CLINICAL INVESTIGATION.2020,50(10):doi:10.1111/eci.13332.
APA：
Yi, Z.-H,Agbana, Y.L,Xiong, G.-H,Ni, Y.-L,Yun, F...&Zhu, Y.-C.(2020).Association between diabetes mellitus and lung cancer: meta-analysis(Open Access).EUROPEAN JOURNAL OF CLINICAL INVESTIGATION,50,(10)
MLA：
Yi, Z.-H,et al."Association between diabetes mellitus and lung cancer: meta-analysis(Open Access)".EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 50..10(2020)
