机构：[a]Department of Rheumatology and Immunology, Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China[b]Xinhua Hospital Chongming Branch Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, China[c]Department of Rheumatology, First Affiliated Hospital of the Medical School, Zhejiang University, Hangzhou, China内科系统风湿免疫科浙江大学医学院附属第一医院[d]Department of Rheumatology and Immunology, People's Hospital of Xinjiang Ugyur Autonomous Region, Urumqi, China[e]Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, China内科科室风湿免疫科昆明医科大学附属第一医院[f]Department of Rheumatology and Immunology, First Affiliated Hospital of Bengbu Medical College, China[g]Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China[h]Shanghai Jiao Tong University School of Medicine, Shanghai, China
出处：
ISSN：
摘要：
OBJECTIVES: As a rare systemic autoinflammatory disease, adult-onset Still's disease (AOSD) has heterogeneous clinical manifestations, response to treatment and outcome. This study tried to assess the clinical characteristics, laboratory tests, and treatments of Chinese AOSD patients, and make a retrospective analysis. METHODS: We collected from 7 hospitals in China a total of 517 Chinese patients with AOSD who satisfied the Yamaguchi criteria. We retrospectively evaluated their clinical features, laboratory tests, treatments and compared them with published data from different studies. All the data in this study were from medical records and further statistic analyses. RESULTS: We evaluated a total of 517 AOSD patients, 72% female, average age of onset was 37.7; spiking fever, rash and arthralgia occurred in 472 (91.3%), 413 (79.9%), 378 (73.1%) cases, respectively. There were 439/513 (85.6%) cases with leukocytosis and 456/476 (95.8%) cases with raised serum ferritin. The highest frequently used medications and regimens for remission were glucocorticoids (498/517, 96.3%), methotrexate (273/517, 52.8%) and hydroxychloroquine (174/517, 33.7%). 84.4%. 357/423 of AOSD cases were able to achieve initial remission with different regimens, mostly including glucocorticoids, methotrexate or hydroxychloroquine. 47.2% of them (244/517) received 30<D≤60 mg/d of prednisone to reach final clinical remission. Further analysis indicated that risk factors, such as skin rash, pericarditis, splenomegaly and delayed diagnosis, are highly related to the dosage of prednisone for remission. CONCLUSIONS: Glucocorticoids are mostly selected to induce remission in China and half of them required ~0.5-1mg/kgbw prednisone. In patients with skin rash, pericarditis, splenomegaly or delayed diagnosis, a higher dosage of prednisone was needed to obtain remission.
语种：
外文
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区医学
小类|3 区风湿病学
最新[2023]版：
大类|4 区医学
小类|4 区风湿病学
第一作者：
第一作者机构：[a]Department of Rheumatology and Immunology, Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital, Shanghai, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Q.-Y,Zeng T,Sun C.-Y,et al.Clinical features and current treatments of adult-onset Still's disease: a multicentre survey of 517 patients in China[J].Clinical and experimental rheumatology.2019,37(6):
APA：
Hu, Q.-Y,Zeng, T,Sun, C.-Y,Luo, C.-N,Liu, S...&Liu, H.-L.(2019).Clinical features and current treatments of adult-onset Still's disease: a multicentre survey of 517 patients in China.Clinical and experimental rheumatology,37,(6)
MLA：
Hu, Q.-Y,et al."Clinical features and current treatments of adult-onset Still's disease: a multicentre survey of 517 patients in China".Clinical and experimental rheumatology 37..6(2019)
