资源类型：
期刊
收录情况：
◇ CSCD-C
文章类型：
综述
机构：
[a]Department of Orthopedics, The first Affiliated Hospital of Kunming Medical University, Kunming, 650032, China
外科科室
骨科
昆明医科大学附属第一医院
[b]Department of Nephrology, Jiangxi Provincial People’s Hospital Nanchang, Nanchang, 330006, China
[c]Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, United States
ISSN：
1674-7984
关键词：
copper
DNA damage
DNA repair
iron
metalloprotein
ROS
摘要：
Cells contain a large number of metalloproteins that commonly harbor at least one metal ion cofactor. In metalloproteins, metal ions are usually coordinated by oxygen, sulfur, or nitrogen centers belonging to amino acid residues in the protein. The presence of the metal ion in metalloproteins allows them to take part in diverse biological processes, such as genome stability, metabolic catalysis, and cell cycle progression. Clinically, alteration of the function of metalloproteins in mammals is genetically associated with diseases characterized by DNA damage and repair defects. The present review focuses on the current perspectives of metal ion homeostasis in different organisms and summarizes the most recent understanding on magnesium, copper, iron, and manganese-containing proteins and their functional involvement in the maintenance of genome stability. © 2016, Higher Education Press and Springer-Verlag Berlin Heidelberg.
第一作者：
Zhang, C
第一作者机构：
[a]Department of Orthopedics, The first Affiliated Hospital of Kunming Medical University, Kunming, 650032, China
共同第一作者：
Zhang, F
通讯作者：
Zhang, C
推荐引用方式(GB/T 7714)：
Zhang C,Zhang F,Zhou P,et al.Functional role of metalloproteins in genome stability[J].Frontiers in Biology.2016,11(2):doi:10.1007/s11515-016-1392-4.
APA：
Zhang, C,Zhang, F,Zhou, P&Zhang, C.(2016).Functional role of metalloproteins in genome stability.Frontiers in Biology,11,(2)
MLA：
Zhang, C,et al."Functional role of metalloproteins in genome stability".Frontiers in Biology 11..2(2016)
