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Effect of montmorillonite powder and mesalazine on intestinal epithelial cell apoptosis in rats with ulcerative colitis

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收录情况: ◇ 北大核心

机构: [a]Department of Pediatrics, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan Province 650032, China [b]Department of Pathology, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan Province 650032, China
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关键词: Mesalazine Montmorillonite powder

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METHODS: Eighty-two male SD rats were randomly divided into a normal group, a model group and three intervention groups including Smecta group, mesalazine group, and mesalazine plus Smecta group. Ulcerative colitis (UC) was induced in rats by the TNBS/ethanol method. The model group was daily treated with normal saline, and the intervention groups were intragastrically treated with Smecta, mesalazine, mesalazine plus Smecta, respectively. Rats were killed on days 5 and 12 after treatment to collect colon specimens. Terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) method was used to assay intestinal cell apoptosis rate.

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第一作者机构: [a]Department of Pediatrics, The First Affiliated Hospital, Kunming Medical University, Kunming, Yunnan Province 650032, China
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