Left ventricular tissue Doppler imaging (TDI) velocities are used to monitor systolic and diastolic function, but it is not known how these may change in a hyperdynamic circulation, as often occurs in anesthesia and critical care medicine. Twenty-six healthy young volunteers were recruited and left ventricular systolic and diastolic tissue Doppler velocities measured at rest, light exercise, strenuous exercise, and recovery (10 minutes after exercise). At rest, TDI velocities significantly decreased from base to apex (P <.001). Within basal, mid, and apical sections, systolic and diastolic peak velocities differed between segments (P <.05), except for systolic middle (P =.094) and late diastolic apical velocities (P =.257). Basal septal velocities differed from basal lateral, for systolic (P =.041) but not diastolic peak values. Inferobasal radial values differed from basal lateral values for both systolic and diastolic velocities (P <.05). Both systolic and diastolic TDI velocities increased significantly in all segments in a proportionate manner with a hyperdynamic circulation. Copyright © 2011 Colin F. Royse et al.