The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor.
机构：[1]Department of Cardiovascular Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland).外科科室普通外科心脏大血管外科(心脏外科)普通外三科(血管外科)昆明医科大学附属第一医院[2]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland).外科科室麻醉手术科（医技）昆明医科大学附属第一医院
BACKGROUND We aimed to investigate the effects of norepinephrine (NE) released from endogenous stores on bacterial translocation of Escherichia coli in mice by administration of 6-hydroxydopamine (6-OHDA), which selectively destroys noradrenergic nerve terminals. MATERIAL AND METHODS E. coli strain BW25113 and its derivatives (BW25113ΔqseC and BW25113ΔqseC pQseC) were used in this study. The serum concentrations of endotoxin were analyzed. The strains BW25113, BW25113ΔqseC, and BW25113ΔqseC pQseC were detected respectively in tissue specimens harvested from mice treated with 6-OHDA. RESULTS Mice treated with BW25113ΔqseC showed reduced levels of bacterial translocation following administration of 6-OHDA compared with mice treated with BW25113. The defect of E. coli QseC receptor caused the norepinephrine-QseC signal chain to be interrupted, and the invasiveness and penetrating power of the bacteria on the intestinal mucosa was weakened, eventually leading to a significant decrease in the incidence of bacterial translocation. CONCLUSIONS NE modulates the interaction of enteric bacterial pathogens with their hosts via QseC. The blockade of the QseC receptor-mediated effects may be useful to attenuate bacterial translocation.
第一作者机构：[1]Department of Cardiovascular Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland).
通讯作者：
通讯机构：[2]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland).
推荐引用方式(GB/T 7714)：
Meng Jun,Chen Huamei,Lv Qin,et al.The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor.[J].MEDICAL SCIENCE MONITOR.2020,26:doi:10.12659/MSM.922986.
APA：
Meng Jun,Chen Huamei,Lv Qin,Luo Xiaodan&Yang Kun.(2020).The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor..MEDICAL SCIENCE MONITOR,26,
MLA：
Meng Jun,et al."The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor.".MEDICAL SCIENCE MONITOR 26.(2020)
