机构:[1]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.[2]Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University, Kunming, Yunnan 650214, China.[3]Department Obstetrics, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China.[4]Department of Nuclear Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, China.内科科室核医学科[5]Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan 650118, China.[6]School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China.[7]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China. E-mail: shih@kust.edu.cn.[8]Kunming Medical University, Kunming, Yunnan 650500, China. E-mail: wenlinwang331@163.com.[9]Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University, Kunming, Yunnan 650214, China. E-mail: 391910123@qq.com.
Osteonecrosis is a common human disease in orthopedics. It is difficult to treat, and half of patients may need artificial joint replacement, resulting in a considerable economic burden and a reduction in quality of life. Hormones are one of the major causes of osteonecrosis and high doses of corticosteroids are considered the most dangerous factor. Because of the complexity of treatment, we still need a better animal model that can be widely used in drug development and testing. Tree shrews are more closely related to primates than rodents. As such, we constructed a successful tree shrew model to establish and evaluate steroid-associated osteonecrosis (SAON). We found that low-dose lipopolysaccharide (LPS) combined with high-dose methylprednisolone (MPS) over 12 weeks could be used to establish a tree shrew model with femoral head necrosis. Serum biochemical and histological analyses showed that an ideal model was obtained. Thus, this work provides a useful animal model for the study of SAON and for the optimization of treatment methods.
第一作者机构:[1]Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.
推荐引用方式(GB/T 7714):
Chen Qi,Ma Zhao-Xia,Xia Li-Bin,et al.A tree shrew model for steroid-associated osteonecrosis.[J].ZOOLOGICAL RESEARCH.2020,41(5):564-568.doi:10.24272/j.issn.2095-8137.2020.061.
APA:
Chen Qi,Ma Zhao-Xia,Xia Li-Bin,Ye Zhen-Ni,Liu Bao-Ling...&Li Yan-Jiao.(2020).A tree shrew model for steroid-associated osteonecrosis..ZOOLOGICAL RESEARCH,41,(5)
MLA:
Chen Qi,et al."A tree shrew model for steroid-associated osteonecrosis.".ZOOLOGICAL RESEARCH 41..5(2020):564-568