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Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.

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收录情况： ◇ SCIE ◇ SSCI

作者：
Bruin Willem B[1] ; Taylor Luke[2] ; Thomas Rajat M[3] ; Shock Jonathan P[4] ; Zhutovsky Paul[3] ; Abe Yoshinari[5] ; Alonso Pino[6,7,8] ; Ameis Stephanie H[9,10] ; Anticevic Alan[11] ; Arnold Paul D[12,13] ; Assogna Francesca[14] ; Benedetti Francesco[15] ; Beucke Jan C[16,17] ; Boedhoe Premika S W[18,19] ; Bollettini Irene[15] ; Bose Anushree[20] ; Brem Silvia[21,22] ; Brennan Brian P[23] ; Buitelaar Jan K[24,25] ; Calvo Rosa[26,27,28] ; Cheng Yuqi[29] ; Cho Kang Ik K[30] ; Dallaspezia Sara[15] ; Denys Damiaan[3,31] ; Ely Benjamin A[32] ; Feusner Jamie D[33] ; Fitzgerald Kate D[34] ; Fouche Jean-Paul[35] ; Fridgeirsson Egill A[3] ; Gruner Patricia[11] ; Gürsel Deniz A[36,37] ; Hauser Tobias U[21,38,39] ; Hirano Yoshiyuki[40] ; Hoexter Marcelo Q[41] ; Hu Hao[42] ; Huyser Chaim[43,44] ; Ivanov Iliyan[45] ; James Anthony[46] ; Jaspers-Fayer Fern[47] ; Kathmann Norbert[16] ; Kaufmann Christian[16] ; Koch Kathrin[36,37] ; Kuno Masaru[40] ; Kvale Gerd[48,49] ; Kwon Jun Soo[50,51] ; Liu Yanni[34] ; Lochner Christine[52] ; Lázaro Luisa[26,27,28,53] ; Marques Paulo[54,55,56] ; Marsh Rachel[57,58] ; Martínez-Zalacaín Ignacio[6,8] ; Mataix-Cols David[59] ; Menchón José M[6,7,8] ; Minuzzi Luciano[60] ; Moreira Pedro S[54,55,56] ; Morer Astrid[26,27,28,53] ; Morgado Pedro[54,55,56] ; Nakagawa Akiko[40] ; Nakamae Takashi[5] ; Nakao Tomohiro[61] ; Narayanaswamy Janardhanan C[20] ; Nurmi Erika L[33] ; O'Neill Joseph[62] ; Pariente Jose C[63] ; Perriello Chris[23,64] ; Piacentini John[33] ; Piras Fabrizio[14] ; Piras Federica[14] ; Reddy Y C Janardhan[20] ; Rus-Oswald Oana G[65,66] ; Sakai Yuki[5,67] ; Sato João R[68] ; Schmaal Lianne[69,70] ; Shimizu Eiji[40,71] ; Simpson H Blair[57,72] ; Soreni Noam[73,74] ; Soriano-Mas Carles[6,7,75] ; Spalletta Gianfranco[14,76] ; Stern Emily R[77,78] ; Stevens Michael C[79,80] ; Stewart S Evelyn[47,81,82] ; Szeszko Philip R[83,84] ; Tolin David F[85,86] ; Venkatasubramanian Ganesan[20] ; Wang Zhen[42,87] ; Yun Je-Yeon[88,89] ; van Rooij Daan[90] ;
机构： [1]Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands. willembenjamin@gmail.com. [2]Department of Physiology, Anatomy and Genetics, Oxford, UK. [3]Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands. [4]Department of mathematics and applied mathematics, University of Cape Town, Cape Town, South Africa. [5]Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. [6]Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. [7]Centro de Investigación Biomèdica en Red de Salud Mental-CIBERSAM, Barcelona, Spain. [8]Department of Clinical Sciences, University of Barcelona, Barcelona, Spain. [9]The Margaret and Wallace McCain Centre for Child, Youth and Family Mental Health, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada. [10]Centre for Brain and Mental Health, The Hospital for Sick Children, Toronto, Canada. [11]Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA. [12]Mathison Centre for Mental Health Research and Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. [13]Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 1N4, Canada. [14]Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. [15]Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy. [16]Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. [17]Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden. [18]Amsterdam UMC, Vrije Universteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands. [19]Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands. [20]Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India. [21]Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. [22]University of Zurich and ETH Zurich, Neuroscience Center Zurich, Zurich, Switzerland. [23]McLean Hospital, Harvard Medical School, Belmont, MA, 02115, USA. [24]Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands. [25]Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands. [26]Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain. [27]Department of Medicine, University of Barcelona, Barcelona, Spain. [28]Centro de Investigación Biomédica en red de Salud Mental (CIBERSAM), Barcelona, Spain. [29]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China. [30]Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. [31]Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands. [32]Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. [33]Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, 94612, USA. [34]Department of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA. [35]Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. [36]Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, München, Germany. [37]TUM-Neuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München, München, Germany. [38]Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, UK. [39]Wellcome Centre for Human Neuroimaging, University College London, London, UK. [40]Research Center for Child Mental Development, Chiba University, Chiba, Japan. [41]Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil. [42]Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine, Shanghai, China. [43]De Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam, The Netherlands. [44]Department of child and adolescent psychiatry Amsterdam UMC, Amsterdam, The Netherlands. [45]Division of Child and Adolescent Psychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. [46]Department of Psychiatry, , Oxford University, Oxford, UK. [47]University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. [48]Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway. [49]Department of Clinical Psychology, University of Bergen, Bergen, Norway. [50]Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. [51]Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Korea. [52]SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. [53]Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [54]Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. [55]ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal. [56]Clinical Academic Center-Braga, Braga, Portugal. [57]Columbia University Irving Medical Center, Columbia University, New York, NY, 10027, USA. [58]The Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY, 10027, USA. [59]Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden. [60]Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, L8S 4L8, Canada. [61]Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. [62]Division of Child and Adolescent Psychiatry, Jane and Terry Semel Institute For Neurosciences, University of California, Los Angeles, CA, 94612, USA. [63]Magnetic Resonance Image Core Facility, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain. [64]University of Illinois at Urbana-Champaign, Champaign, IL, 61820, USA. [65]University of Zürich, University Hospital Zürich, Dept. Neuroradiology, Zürich, Switzerland. [66]University Department of Geriatric Medicine Felix Platter, Basel, Switzerland. [67]ATR Brain Information Communication Research Laboratory Group, Kyoto, Japan. [68]Center of Mathematics, Computing and Cognition, Universidade Federal do ABC, Santo Andre, Brazil. [69]Orygen, Parkville, VIC, Australia. [70]Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, 3052, Australia. [71]Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan. [72]Center for OCD and Related Disorders, New York State Psychiatric Institute, New York, NY, 10032, USA. [73]Pediatric OCD Consultation service, Anxiety Treatment and Research Center, St. Joseph's HealthCare, Hamilton, ON, L9C 0E3, Canada. [74]Offord Child Center, McMaster University, Hamilton, ON, L8S 4L8, Canada. [75]Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain. [76]Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, 77030, USA. [77]Department of Psychiatry, New York University Langone School of Medicine, New York, NY, 10016, USA. [78]Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, USA. [79]Olin Neuropsychiatry Research Center, Hartford Hospital, Hartford, CT, 06106, USA. [80]Department of Psychiatry, Yale University School of Medicine, New Haven, 06510, USA. [81]British Columbia Children's Hospital, Vancouver, BC, V6H 3N1, Canada. [82]British Columbia Mental Health and Addictions Research Institute, Vancouver, BC, V6H 3N1, Canada. [83]Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. [84]James J. Peters VA Medical Center, Bronx, New York, NY, 10468, USA. [85]Institute of Living/Hartford Hospital, Hartford, CT, 06119, USA. [86]Yale University School of Medicine, New Haven, CT, 06510, USA. [87]Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. [88]Seoul National University Hospital, Seoul, Republic of Korea. [89]Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea. [90]Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands. [91]Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90007, USA. [92]SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa. [93]Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands. g.a.vanwingen@amsterdamumc.nl.
出处：
DOI： 10.1038/s41398-020-01013-y
ISSN：

摘要：
No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.

基金：
NIH BD2K (Big Data to Knowledge) awardUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [U54 EB020403]; Neuroscience Amsterdam; Japan Society for the Promotion of Science (JSPS; KAKENHI)Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [18K15523, 16K19778, 18K07608, 16K04344, 19K03309, 26461762]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo Research Foundation)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2011/21357-9, 2018/04654-9, 2018/21934-5]; EU FP7 project TACTICSEuropean Union (EU) [278948]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81560233, 81371340]; International ObsessiveCompulsive Disorder Foundation (IOCDF) Research Award; Dutch Organization for Scientific Research (NWO)Netherlands Organization for Scientific Research (NWO) [912-02-050, 907-00-012, 940-37-018, 916.86.038]; Netherlands Society for Scientific Research (NWO-ZonMw VENI grant) [916.86.036]; Netherlands Society for Scientific Research (NWOZonMw AGIKO stipend) [920-03-542]; NARSAD Young Investigator AwardNARSAD; Netherlands Brain Foundation [2010(1)-50]; Federal Ministry of Education and Research of GermanyFederal Ministry of Education & Research (BMBF) [BMBF-01GW0724]; Alberta Innovates Translational Health Chair in Child and Youth Mental Health; Ontario Brain Institute; Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [KO 3744/7-1]; Helse Vest Health Authority [911754, 911880]; Norwegian Research CouncilResearch Council of Norway [HELSEFORSK 243675]; Wellcome TrustWellcome Trust; South London and Maudsley Trust, London, UK [064846]; Generalitat de Catalunya (AGAUR)Agencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR)Generalitat de Catalunya [2017 SGR 1247]; PhDiHES program (FCT fellowship Grant) [PDE/BDE/113601/2015]; Japanese Ministry of Education, Culture, Sports, Science and TechnologyMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [22591262, 25461732, 16K10253]; Italian Ministry of HealthMinistry of Health, Italy [RC13-14-15-16-17-18A]; National Center for Advancing Translational SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000067/KL2TR00069]; SA MRC funding; National Research Foundation of South AfricaNational Research Foundation - South Africa; Canadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR); Michael Smith Foundation for Health ResearchMichael Smith Foundation for Health Research; British Columbia Provincial Health Services Authority funding; Netherlands Organization for Scientific Research (NWO/ZonMW Vidi) [917.15.318]; Wellcome-DBT India AllianceWellcome Trust DBT India Alliance [500236/Z/11/Z]; Shanghai Key Laboratory of Psychotic Disorders [13dz2260500]; Government of India grants from the Department of Science and Technology [SR/S0/HS/0016/2011]; Government of India grants from the Department of Science and Technology (DST INSPIRE faculty grant) [IFA12-LSBM-26]; Department of Biotechnology [BT/PR13334/Med/30/259/2009, BT/06/IYBA/2012]; Dana Foundation; NARSADNARSAD; NIMHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R01 MH107419, K23MH082176, R21MH093889, K23MH104515, R33MH107589, R01MH111794, R01 MH081864, R01 MH085900, K23 MH115206]; NIMHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH); David Judah Fund at the Massachusetts General Hospital [K23-MH092397]; Marato TV3 Foundation [01/2010, 091710]; Carlos III Health InstituteInstituto de Salud Carlos III [PI040829, CPII16/00048, PI13/01958, PI16/00889, PI14/00419, FI17/00294, PI16/00950]; FEDER funds/European Regional Development Fund (ERDF), a way to build EuropeEuropean Union (EU); AGAURAgencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR) [2017 SGR 881]; Japan Agency for Medical Research and Development (AMED Brain/MINDS Beyond program Grant) [JP19dm0307002]; Oxford Health Services Research Committee; National Institute on Drug AbuseUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA); NIH/NIDAUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA) [R21/DA046029, R21/DA045218]; Wellcome; Royal SocietyRoyal Society of London [211155/Z/18/Z]; Jacobs Foundation [2017-1261-04]; Medical Research FoundationMedical Research Council UK (MRC); Brain and Behavior Research Foundation (2018 NARSAD Young Investigator grant) [27023]; Swiss National Science Foundation (SNSF)Swiss National Science Foundation (SNSF) [320030_130237]; Harmann Muller foundation [1460]; NHMRC Career Development FellowshipNational Health and Medical Research Council of Australia [1140764]; [IPB grant]
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外文
被引次数：
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 精神病学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 精神病学
JCR分区：
出版当年[2020]版：
Q1 PSYCHIATRY
最新[2023]版：
Q1 PSYCHIATRY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands. willembenjamin@gmail.com.
推荐引用方式(GB/T 7714)：
Bruin Willem B,Taylor Luke,Thomas Rajat M,et al.Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.[J].TRANSLATIONAL PSYCHIATRY.2020,10(1):doi:10.1038/s41398-020-01013-y.
APA：
Bruin Willem B,Taylor Luke,Thomas Rajat M,Shock Jonathan P,Zhutovsky Paul...&van Rooij Daan.(2020).Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters..TRANSLATIONAL PSYCHIATRY,10,(1)
MLA：
Bruin Willem B,et al."Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.".TRANSLATIONAL PSYCHIATRY 10..1(2020)

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