Introduction A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated. Methods This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia. Results Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that >= 4 hospitalizations (OR = 1.78,P= .004), tobacco dependence (OR = 1.48,P= .006), alcohol dependence (OR = 1.74,P= .013), and physical illness (OR = 1.89,P= .001) were independently and significantly associated with a family history of mental disease. Conclusion Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.
基金:
Priority of Shanghai key discipline of medicine [2017ZZ02020]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2016YFC1306805]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471359]; Shanghai Science and technology committeeShanghai Science & Technology Committee [14411963400]