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Clinical characteristics of familial schizophrenia

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机构: [1]Shanghai Jiao Tong Univ, Dept Psychiat, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China [2]Tongji Univ, Dept Psychiat, Shanghai Tongji Hosp, 389 Xincun Rd, Shanghai 200065, Peoples R China [3]Cent South Univ, Mental Hlth Inst, Second Xiangya Hosp, Changsha, Peoples R China [4]Chinese Journal Psychiat, Editorial Off, Beijing, Peoples R China [5]Peking Univ, Beijing Mental Hlth Inst, Beijing, Peoples R China [6]Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China [7]Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China [8]Harbin Med Univ, Dept Psychiat, Affiliated Hosp 1, Harbin, Peoples R China [9]Tianjing Anding Hosp, Dept Psychiat, Tianjin, Peoples R China [10]Xiaoshan Hosp Zhejiang Prov, Dept Psychiat, Hangzhou, Peoples R China [11]Zhejiang Univ, Dept Psychiat, Affiliated Hosp 2, Sch Med, Hangzhou, Peoples R China [12]Tongde Hosp Zhejiang Prov, Dept Psychiat, Hangzhou, Peoples R China [13]Ningbo Kangning Hosp, Dept Psychiat, Ningbo, Peoples R China [14]Xinxiang Med Coll, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China [15]Qingdao Seventh Peoples Hosp, Dept Psychiat, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China [16]Guangzhou Med Univ, Dept Psychiat, Guangzhou Psychiat Hosp, Affiliated Brain Hosp, Guangzhou, Peoples R China [17]Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou, Peoples R China [18]Shenzhen Kangning Hosp, Dept Psychiat, Shenzhen, Peoples R China [19]Guangzhou Med Univ, Dept Psychiat, Guangdong Mental Hlth Ctr, Foshan, Peoples R China [20]Sichuan Univ, Dept Psychiat, West China Hosp, Chengdu, Peoples R China [21]Kunming Med Univ, Dept Psychiat, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China [22]Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China [23]Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan, Peoples R China [24]Nanjing Med Univ, Nanjing Brain Hosp, Dept Clin Psychol, Nanjing, Peoples R China [25]Suzhou Guangji Hosp, Dept Psychiat, Suzhou, Peoples R China [26]Xijing Hosp, Dept Psychiat, Xian, Peoples R China [27]Univ South China, Dept Psychiat, Affiliated Hosp 1, Hengyang, Peoples R China [28]Cent South Univ, Dept Psychiat, Xiangya Hosp, Changsha, Peoples R China
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关键词: familial history risk schizophrenia sporadic symptom

摘要:
Introduction A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated. Methods This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia. Results Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that >= 4 hospitalizations (OR = 1.78,P= .004), tobacco dependence (OR = 1.48,P= .006), alcohol dependence (OR = 1.74,P= .013), and physical illness (OR = 1.89,P= .001) were independently and significantly associated with a family history of mental disease. Conclusion Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.

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出版当年[2022]版:
大类 | 4 区 医学
小类 | 4 区 精神病学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 精神病学
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出版当年[2021]版:
Q2 PSYCHIATRY Q3 PSYCHIATRY
最新[2023]版:
Q2 PSYCHIATRY

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第一作者机构: [1]Shanghai Jiao Tong Univ, Dept Psychiat, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China [2]Tongji Univ, Dept Psychiat, Shanghai Tongji Hosp, 389 Xincun Rd, Shanghai 200065, Peoples R China
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通讯机构: [2]Tongji Univ, Dept Psychiat, Shanghai Tongji Hosp, 389 Xincun Rd, Shanghai 200065, Peoples R China
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