国家自然科学基金面上项目(81772575、81972314)%中国医学科学院医学健康科技创新工程(2016-I2M-1-001)%浙江省科技厅重点研发计划(2015C03030)%National Natural Science Foundation of China(81772575, 81972314)%CAMS Innovation Fund for Medical Sciences (CIFMS)(2016-I2M-1-001)%Technologies Research and Development Program of Zhejiang Provincial Department of Science and Technology(2015C03030)