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LncRNA Sirt1-AS upregulates Sirt1 to attenuate aging related deep venous thrombosis.

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收录情况： ◇ SCIE ◇ 预警期刊

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机构： [1]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China [2]Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an 710054, Shaanxi, China [3]Department of Ultrasonography, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China

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关键词： long non-coding RNA Sirt1-AS silent information regulator 1 deep vein thrombosis senescence human vascular endothelial cells

摘要：

Aging is associated with the increased incidence of deep venous thrombosis (DVT), resulting in significant morbidity and mortality in the elderly, but the underlying mechanism is elusive. Silent information regulator 1 (Sirt1) is linked to the senescence, inflammation, oxidative stress and platelet adhesion of endothelial cells. Here we showed that DVT was associated with the senescence of endothelium and lower expression of Sirt1. Furthermore, Sirt1 could inhibit endothelial senescence and reduce the occurrence of DVT. Interestingly, we found antisense long non-coding RNA (lncRNA Sirt1-AS) upregulated Sirt1, decreased the expression of senescence and DVT associated biomarkers in human vascular endothelial cells (HUVECs). In addition, lncRNA Sirt1-AS overexpression alleviated DVT through upregulating Sirt1 and thereby inducing Foxo3a degradation. In conclusion, our findings demonstrate that lncRNA Sirt1-AS may be a potential new biomarker for DVT.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 3 区老年医学 3 区细胞生物学

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无

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出版当年[2021]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

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无

影响因子： 0 最新[2024版] 0 最新五年平均 5.955 出版当年[2021版] 6.458 出版当年五年平均 5.682 出版前一年[2020版] 5.2 出版后一年[2022版]

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第一作者机构： [1]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China

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