机构：[1]Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong SAR.[2]Department of Obstetrics and Gynecology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.[3]Department of Obstetrics and Gynecology, Suzhou Municipal Hospital, Suzhou, China.[4]Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.[5]Department of Obstetrics, The First Affiliated Hospital of Kunming Medical University, Kunming, China.外科科室妇产科产科昆明医科大学附属第一医院
Our objectives were to compare the single-line and two-line methods of cervical length measurement in the first trimester of pregnancy and to evaluate the potential value of the first trimester cervical length measured by the two methods in predicting spontaneous preterm birth.
This was a prospective study in singleton pregnancies at 11+0 -13+6 weeks of gestation. Cervical length was measured by two methods: (i) a linear distance between the two ends of the glandular area around the endocervical canal (single-line method) and (ii) a sum of a linear distance from the internal os to the greatest cervical curvature and a linear distance from this point of the cervix to the external os (two-line method). The screening performance of the first trimester cervical length measured by the two different methods for the prediction of spontaneous preterm delivery was assessed by receiver-operating characteristics (ROC) curve analysis. The areas under the ROCs (AUROC) were compared by De Long test.
A total of 1484 consecutive singleton pregnancies were included in this study. Spontaneous preterm delivery at <37 weeks and <32 weeks occurred in 75 cases (5.1%) and 12 cases (0.8%), respectively. The median cervical length measured by the single-line method was significantly shorter than that by the two-line method (33.5 mm vs 36.5 mm, P<0.001). Compared to the term delivery group, the median cervical length measured by the two-line method was shorter in women with spontaneous delivery at <32 weeks of gestation (36.5 mm vs 33.6 mm, P<0.01). No significant difference in the median cervical length measured by the single-line method was detected between the spontaneous preterm delivery and term delivery groups. Receiver-operating-characteristic curves demonstrated that cervical length measured by the two-line method achieved better performance in predicting spontaneous delivery at <32 weeks than the single-line method (AUROC: 0.72 vs 0.61, P<0.01).
We have demonstrated that the first trimester cervical length, measured by the two-line approach, holds promise as a potential screening tool for early spontaneous preterm delivery.
This article is protected by copyright. All rights reserved.
基金：
The study is supported by Innovation and
Technology Fund (ITF No: ITS/252/17FX)
and a start up grant from the Faculty of
Medicine, The Chinese University of Hong
Kong.
第一作者机构：[1]Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong SAR.
通讯作者：
通讯机构：[1]Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong SAR.[*1]Department of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR.
推荐引用方式(GB/T 7714)：
Feng Qiaoli,Duan Honglei,Ju Xiaoqing,et al.Prediction of spontaneous preterm birth by cervical length in the first trimester of pregnancy: comparison of two measurement methods.[J].ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA.2021,100(7):1305-1312.doi:10.1111/aogs.14138.
APA：
Feng Qiaoli,Duan Honglei,Ju Xiaoqing,Appiah Kubi,Yip Ka Man...&Poon Liona C.(2021).Prediction of spontaneous preterm birth by cervical length in the first trimester of pregnancy: comparison of two measurement methods..ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA,100,(7)
MLA：
Feng Qiaoli,et al."Prediction of spontaneous preterm birth by cervical length in the first trimester of pregnancy: comparison of two measurement methods.".ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 100..7(2021):1305-1312
