Validity of the MemTrax Memory Test Compared to the Montreal Cognitive Assessment in the Detection of Mild Cognitive Impairment and Dementia due to Alzheimer's Disease in a Chinese Cohort.
机构：[a]Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China内科科室神经内科昆明医科大学附属第一医院[b]Yunnan Provincial Clinical Research Center for Neurological Diseases, Yunnan, China[c]SJN Biomed Ltd., Kunming, Yunnan, China[d]Center for Alzheimer’s Research, Washington Institute of Clinical Research, Vienna, VA, USA[e]Neurosurgery Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China外科科室神经外科神经外一科（神经外科）昆明医科大学附属第一医院[f]Department of Public Health, Chengdu Medical College, Sichuan, China[g]Bothwin Clinical Study Consultant, Shanghai, China[h]Department of Neurology, Dehong People’s Hospital, Dehong, Yunnan, China[i]Department of Rehabilitation Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China医技科室康复医学科昆明医科大学附属第一医院[j]SIVOTEC Analytics, Boca Raton, FL, USA[k]War Related Illness and Injury Study Center, VA Palo Alto HCS, Palo Alto, CA, USA[l]Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
A valid, reliable, accessible, engaging, and affordable digital cognitive screen instrument for clinical use is in urgent demand.
To assess the clinical utility of the MemTrax memory test for early detection of cognitive impairment in a Chinese cohort.
The 2.5-minute MemTrax and the Montreal Cognitive Assessment (MoCA) were performed by 50 clinically diagnosed cognitively normal (CON), 50 mild cognitive impairment due to AD (MCI-AD), and 50 Alzheimer's disease (AD) volunteer participants. The percentage of correct responses (MTx-% C), the mean response time (MTx-RT), and the composite scores (MTx-Cp) of MemTrax and the MoCA scores were comparatively analyzed and receiver operating characteristic (ROC) curves generated.
Multivariate linear regression analyses indicated MTx-% C, MTx-Cp, and the MoCA score were significantly lower in MCI-AD versus CON and in AD versus MCI-AD groups (all with p≤0.001). For the differentiation of MCI-AD from CON, an optimized MTx-% C cutoff of 81% had 72% sensitivity and 84% specificity with an area under the curve (AUC) of 0.839, whereas the MoCA score of 23 had 54% sensitivity and 86% specificity with an AUC of 0.740. For the differentiation of AD from MCI-AD, MTx-Cp of 43.0 had 70% sensitivity and 82% specificity with an AUC of 0.799, whereas the MoCA score of 20 had 84% sensitivity and 62% specificity with an AUC of 0.767.
MemTrax can effectively detect both clinically diagnosed MCI and AD with better accuracy as compared to the MoCA based on AUCs in a Chinese cohort.
基金：
MD Scientific Research
Program of Kunming Medical University (Grant no.
2017BS028 to X.L.) and the Research Program of
Yunnan Science and Technology Department (Grant
no. 2019FE001(–222) to X.L).
第一作者机构：[a]Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China[b]Yunnan Provincial Clinical Research Center for Neurological Diseases, Yunnan, China[*1]Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
推荐引用方式(GB/T 7714)：
Liu Xiaolei,Chen Xinjie,Zhou Xianbo,et al.Validity of the MemTrax Memory Test Compared to the Montreal Cognitive Assessment in the Detection of Mild Cognitive Impairment and Dementia due to Alzheimer's Disease in a Chinese Cohort.[J].JOURNAL OF ALZHEIMERS DISEASE.2021,80(3):1257-1267.doi:10.3233/JAD-200936.
APA：
Liu Xiaolei,Chen Xinjie,Zhou Xianbo,Shang Yajun,Xu Fan...&Zhong Lianmei.(2021).Validity of the MemTrax Memory Test Compared to the Montreal Cognitive Assessment in the Detection of Mild Cognitive Impairment and Dementia due to Alzheimer's Disease in a Chinese Cohort..JOURNAL OF ALZHEIMERS DISEASE,80,(3)
MLA：
Liu Xiaolei,et al."Validity of the MemTrax Memory Test Compared to the Montreal Cognitive Assessment in the Detection of Mild Cognitive Impairment and Dementia due to Alzheimer's Disease in a Chinese Cohort.".JOURNAL OF ALZHEIMERS DISEASE 80..3(2021):1257-1267
