We describe a case of recurrent and metastatic radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) treated with anlotinib in this report. The patient was randomized to placebo initially, after disease progressed at C8 (C is the treatment cycle), the patient was referred to the open label therapy of anlotinib, 12 mg p.o. daily with a 2-week on/1-week off regimen. Partial response was achieved at C2 with anlotinib treatment. To date, over 37 months of progression-free survival (PFS) has been achieved. Adverse effects were tolerable and manageable in this patient. Molecular characterization revealed coexistent C228T mutation of TERT promoter and BRAF(V600E) mutations. Favorable clinical outcome in this patient suggests that anlotinib might provide a novel effective therapeutic option for patients with RAIR-DTC. TERT and BRAF(V600E) mutations may represent as biomarker for predicting salutary effects of anlotinib.
基金：
High-level Health Talents Project of Yunnan Provincial [H-2017036]; Jiangsu Chia-tai Tianqing Pharmaceutical Co. Ltd
第一作者机构：[1]Department of Thyroid Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China
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推荐引用方式(GB/T 7714)：
Su Yanjun,Cheng Shaohao,Qian Jun,et al.Case Report: Anlotinib Therapy in a Patient With Recurrent and Metastatic RAIR-DTC Harboring Coexistent TERT Promoter and BRAF(V600E) Mutations[J].FRONTIERS IN ONCOLOGY.2021,11:doi:10.3389/fonc.2021.626076.
APA：
Su, Yanjun,Cheng, Shaohao,Qian, Jun,Zhang, Min,Li, Tuanli...&Cheng, Ruochuan.(2021).Case Report: Anlotinib Therapy in a Patient With Recurrent and Metastatic RAIR-DTC Harboring Coexistent TERT Promoter and BRAF(V600E) Mutations.FRONTIERS IN ONCOLOGY,11,
MLA：
Su, Yanjun,et al."Case Report: Anlotinib Therapy in a Patient With Recurrent and Metastatic RAIR-DTC Harboring Coexistent TERT Promoter and BRAF(V600E) Mutations".FRONTIERS IN ONCOLOGY 11.(2021)
