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EphA2: A promising therapeutic target in breast cancer

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收录情况： ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊

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机构： [a]Department of the First Breast Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China [b]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China [c]Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China [d]KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China [e]Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, China

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关键词： ADC Breast cancer EphA2 EphrinA1 Targeted therapy

摘要：

EphA2 (ephrin type-A receptor 2), a receptor tyrosine kinase, is overexpressed in human breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression, such as proliferation, survival, migration, invasion, drug resistance, metastasis, and angiogenesis. As its inhibition through multiple approaches can inhibit the growth of breast cancer and restore drug sensitivity, EphA2 has become a promising therapeutic target for breast cancer treatment. Here, we summarize the expression, functions, mechanisms of action, and regulation of EphA2 in breast cancer. We also list the potential therapeutic strategies targeting EphA2. Furthermore, we discuss the future directions of studying EphA2 in breast cancer. © 2021 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China

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出版当年[2022]版：

大类 | 2 区生物学

小类 | 2 区遗传学 3 区生化与分子生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 3 区生化与分子生物学 3 区遗传学

第一作者：

第一作者机构： [a]Department of the First Breast Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China

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通讯作者：

通讯机构： [b]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China [d]KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China [e]Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, China

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EphA2: A promising therapeutic target in breast cancer

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