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Structural Brain Correlates in Major Depression, Anxiety Disorders and Post-traumatic Stress Disorder: A Voxel-Based Morphometry Meta-analysis.

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机构: [a]Mental Health Department, Hospital Universitari Parc Taulí, Institut d’Investigació i Innovació Parc Taulí (I3PT), Spain [b]Department of Psychology, Abat Oliba CEU University, Spain [c]Programa E-Health ICOnnecta’t, Institut Català d’Oncologia, Barcelona, Spain [d]Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain [e]Early Psychosis: Interventions and Clinical-detection (EPIC) lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom [f]Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, Spain [g]Institut d’Investigació Biomèdica de Bellvitge-IDIBELL, Department of Psychiatry, Bellvitge University Hospital, Spain [h]Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona, Spain [i]Hospital General de Granollers, Spain [j]Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spain [k]Department of Psychiatry and Behavioral Science, College of Medicine and Health Sciences, United Arab Emirates University (UAEU), United Arab Emirates [l]Centre for Affective Disorders, Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom [m]Department of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital (CHUV), Lausanne Switzerland [n]Department of Psychiatry, Service of Child and Adolescent Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland [o]Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Australia [p]FIDMAG Research Foundation, Germanes Hospitalàries, Spain [q]Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), Switzerland [r]Humboldt-Universität zu Berlin, Department of Psychology, Berlin, Germany [s]Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London & Division of the Humanities and Social Sciences, California Institute of Technology, Caltech, EEUU [t]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China [u]Department of Psychiatry and Medical Psychology, and Research Institute at Medical University of Plovdiv, Bulgaria [v]Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden [w]Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden [x]Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spain [y]Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain [z]Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Spain. [aa]Carlos III Health Institute, Mental Health Networking Biomedical Research Centre (CIBERSAM)
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The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.Copyright © 2021. Published by Elsevier Ltd.

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出版当年[2022]版
大类 | 1 区 医学
小类 | 1 区 行为科学 2 区 神经科学
最新[2023]版
大类 | 1 区 医学
小类 | 1 区 行为科学 2 区 神经科学
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出版当年[2021]版:
Q1 BEHAVIORAL SCIENCES Q1 NEUROSCIENCES
最新[2023]版:
Q1 BEHAVIORAL SCIENCES Q1 NEUROSCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [a]Mental Health Department, Hospital Universitari Parc Taulí, Institut d’Investigació i Innovació Parc Taulí (I3PT), Spain [b]Department of Psychology, Abat Oliba CEU University, Spain [c]Programa E-Health ICOnnecta’t, Institut Català d’Oncologia, Barcelona, Spain [aa]Carlos III Health Institute, Mental Health Networking Biomedical Research Centre (CIBERSAM)
通讯作者:
通讯机构: [a]Mental Health Department, Hospital Universitari Parc Taulí, Institut d’Investigació i Innovació Parc Taulí (I3PT), Spain [x]Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spain [y]Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain [z]Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Spain. [aa]Carlos III Health Institute, Mental Health Networking Biomedical Research Centre (CIBERSAM) [*1]Hospital Sant Joan de Déu of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues de Llobregat, Barcelona, Spain [*2]Hospital Universitari Parc Taulí ,Parc Taulí 1 08208 Sabadell, Barcelona, Spain.
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