机构：[1]Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.浙江大学医学院附属第一医院[2]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.[3]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.[4]International Big-Data Center for Depression Research, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.[5]Department of Rehabilitation Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.浙江大学医学院附属第一医院[6]Center for Cognitive Science of Language, Beijing Language and Culture University, Beijing, China.[7]Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.[8]Sino-Danish Center for Education and Research, Beijing, China.[9]Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.[10]Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.[11]Anhui Medical University, Hefei, Anhui, China.[12]Beijing Anding Hospital, Capital Medical University, Beijing, China.[13]Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.重庆医科大学附属第一医院[14]The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.[15]Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.[16]The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.[17]First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.昆明医科大学附属第一医院[18]Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.[19]Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[20]Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[21]Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China.[22]Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.[23]Affiliated Mental Health Center & Hangzhou Seventh People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.[24]Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[25]Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.[26]The Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.[27]Faculty of Psychology, Southwest University, Chongqing, China.[28]Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou, Zhejiang, China.[29]National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.[30]Xi’an Central Hospital, Xi’an, Shaanxi, China.[31]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, China.[32]Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, Zhejiang, China.[33]Institute of Neuroscience, Chongqing Medical University, Chongqing, China.[34]Chongqing Key Laboratory of Neurobiology, Chongqing, China.[35]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.重庆医科大学附属第一医院[36]Center for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.[37]Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, China.[38]First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.[39]Laboratory of Psychological Health and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[40]Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[41]State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.[42]Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data sample of MDD patients from the REST-meta-MDD Project, including 821 MDD patients and 765 normal controls (NCs) from 16 sites. Using the Dosenbach 160 node atlas, we examined whole-brain functional networks and extracted topological features (e.g., global and local efficiency, nodal efficiency, and degree) using graph theory-based methods. Linear mixed-effect models were used for group comparisons to control for site variability; robustness of results was confirmed (e.g., multiple topological parameters, different node definitions, and several head motion control strategies were applied). We found decreased global and local efficiency in patients with MDD compared to NCs. At the nodal level, patients with MDD were characterized by decreased nodal degrees in the somatomotor network (SMN), dorsal attention network (DAN) and visual network (VN) and decreased nodal efficiency in the default mode network (DMN), SMN, DAN, and VN. These topological differences were mostly driven by recurrent MDD patients, rather than first-episode drug naive (FEDN) patients with MDD. In this highly powered multisite study, we observed disrupted topological architecture of functional brain networks in MDD, suggesting both locally and globally decreased efficiency in brain networks.
基金：
This work was funded by the National Key R&D Program of China No.
2017YFC1309902, the National Natural Science Foundation of China No. 81671774,
No. 81820108018, and No. 81630031, the 13th Five-year Informatization Plan of
Chinese Academy of Sciences No. XXH13505, the Key Research Program of the
Chinese Academy of Sciences No. ZDBS-SSW-JSC006, Beijing Nova Program of
Science and Technology No. Z191100001119104, the Scientific Foundation of
Institute of Psychology, Chinese Academy of Sciences No. Y9CX422005, the China
Postdoctoral Science Foundation No. 2019M660847, the China National Postdoctoral
Program for Innovative Talents No. BX20200360, the Key Project of Science and
Technology Research Plan, Jinhua No. 2020-3-016, the Key research and development
program, Ministry of Science and Technology of People’s Republic of China No.
2019YFC0121003, the Basic Public Welfare Research Program of Zhejiang Province
No. LGF20H090013, and the Start-up Funds for Leading Talents at Beijing Normal
University and National Basic Science Data Center “Chinese Data-sharing Warehouse
for In-vivo Imaging Brain” No. NBSDC-DB-15.
第一作者机构：[1]Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
共同第一作者：
通讯作者：
通讯机构：[2]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.[3]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.[4]International Big-Data Center for Depression Research, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.[42]Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
推荐引用方式(GB/T 7714)：
Hong Yang,Xiao Chen,Zuo-Bing Chen,et al.Disrupted intrinsic functional brain topology in patients with major depressive disorder[J].MOLECULAR PSYCHIATRY.2021,26(12):7363-7371.doi:10.1038/s41380-021-01247-2.
APA：
Hong Yang,Xiao Chen,Zuo-Bing Chen,Le Li,Xue-Ying Li...&Chao-Gan Yan.(2021).Disrupted intrinsic functional brain topology in patients with major depressive disorder.MOLECULAR PSYCHIATRY,26,(12)
MLA：
Hong Yang,et al."Disrupted intrinsic functional brain topology in patients with major depressive disorder".MOLECULAR PSYCHIATRY 26..12(2021):7363-7371
医学