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Transcatheter closure for postinfarction ventricular septal defect: A meta-analysis of the current evidence

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机构: [1]Department of Obsterics Ultrasound, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650034, China [2]Department of Ultrasound Echocardiography, Yanan Hospital of Kunming City, Yunnan Cardiovascular Hospital, Kunming, Yunnan, 650233, China [3]Department of Neurosurgery, The Affiliated Hospital of Yunnan University, The Second People's Hospital of Yunnan, Kunming, Yunnan, 650021, China [4]Department of Cardiovascular Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China [5]Department of Cardiovascular Medicine, Sir Run Run Hospital Affiliated Nanjing Medical University, Nanjing, Jiangsu, 211166, China
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关键词: acute myocardial infarction meta-analysis postinfarction ventricular septal defect transcatheter closure

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Objective Postinfarction ventricular septal defect (PIVSD) is a severe complication of acute myocardial infarction (AMI). Transcatheter closure (TCC) is an alternative option to surgical repair. This study was undertaken to examine the published literature to provide objective evidence for TCC using a meta-analysis. Methods We searched for significant medical and publisher databases. Two reviewers checked the quality of the studies and extracted data. Eligible studies included single-arm studies and comparative studies. Weighted means, pooled event rates, efficacy outcomes and odds ratios (ORs) for immediate shunt reduction (ISR), presence of cardiogenic shock (CS), New York Heart Association (NYHA) class IV, time from AMI to ventricular septal defect (VSD), and time to VSD closure was estimated. Results A total of 27 single-arm articles (462 patients) were included. The pooled event rate was 89.7% (95% confidence interval [CI]: 0.772-1.021) for successful device implantation, 80.9% (95% CI: 0.645-0.972) for ISR, 31.5% (95% CI: 0.149-0.482) for 30-day mortality, and 25.3% (95% CI: 0.072-0.434) for 30-day mortality of primary closure at the acute phase. CS (OR = 3.607, 95% CI: 2.301-5.653), NYHA class IV (OR = 6.491, 95% CI: 1.444-29.188) and time to VSD closure were risk predictors for TCC. There was no correlation between defect size (OR = 2.592, 95% CI: 0.380-17.661) and mortality. Conclusion TCC should be a relatively safe and minimally invasive method for PIVSD, with an excellent successful device implantation rate and acceptable low 30-day mortality. The procedure appears promising, but its safety and efficacy could only be demonstrated by randomized controlled trials. Therefore, the mortality of data comparing surgery to TCC compels the need for future comparative trials.

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出版当年[2022]版:
大类 | 4 区 医学
小类 | 4 区 心脏和心血管系统 4 区 外科
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 心脏和心血管系统 4 区 外科
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出版当年[2021]版:
Q3 SURGERY Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
最新[2023]版:
Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Q3 SURGERY

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第一作者机构: [1]Department of Obsterics Ultrasound, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650034, China [2]Department of Ultrasound Echocardiography, Yanan Hospital of Kunming City, Yunnan Cardiovascular Hospital, Kunming, Yunnan, 650233, China
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通讯机构: [5]Department of Cardiovascular Medicine, Sir Run Run Hospital Affiliated Nanjing Medical University, Nanjing, Jiangsu, 211166, China [*1]Department of Cardiovascular Medicine, Sir Run Run Hospital Affiliated Nanjing Medical University, 109 Long Mian Avenue, Jiangning District, Nanjing, 211166, China.
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