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Mesenchymal stem cells prevent ovariectomy-induced osteoporosis formation in mice through intraosseous vascular remodeling.

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收录情况： ◇ SCIE

作者：
Wang Weizhou[1,2] ; Wang Yanghao[1,2] ; Tang Zhihong[5] ; Chen Yongcheng[1,2] ; Liu Zhui[1,2] ; Duan Hao[1] ; Zhong Zongyu[1] ; He Fei[1,3,4,*1] ;
机构： [1]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Yunnan, China [2]Kunming Medical University, Yunnan, China [3]Yunnan Province Stem Cell Technology Application Research Center, Yunnan, China [4]Yunnan Provincial Clinical Medical Center for Bone and Joint Diseases, Yunnan, China [5]Department of orthopaedics, People's Hospital of Guang'an City, Sichuan, China
出处：
DOI： 10.1016/j.bbrc.2021.10.033
ISSN：

摘要：
Mesenchymal stem cells (MSCs) can promote osteogenesis and are a promising therapy for postmenopausal osteoporosis. However, the relationship between improved intraosseous microcirculation and increased bone mass induced by MSCs in postmenopausal osteoporosis remains unclear. After the primary MSCs were characterized, they were transplanted into ovariectomized mice. MSCs transplantation enhanced the trabecular number, trabecular bone volume/total volume, and trabecular bone mineral density in ovariectomized mice. To determine the role of MSCs in vascular repair, mice were subjected to femoral artery ligation. Through laser speckle flowmetry, vascular perfusion and femoral trabecular bone and cortical bone analyses, we determined the effects of MSCs in promoting intraosseous angiogenesis and preventing osteoporosis in mice. MSCs effectively prevented postmenopausal osteoporosis development, which is associated with the involvement of MSCs in reestablishment of microcirculation within the skeleton.Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
Yunnan Major Science and Technology Special Projects (2019ZF002), National Natural Science Foundation of China (82160417), Yunnan Outstanding Medical Academic Leader Project (L-201621), Yunnan Industrial Technology Leader Program (YLXL20170046), Yunnan Provincial Education Department Scientific Research Foundation (2020Y0123), Yunnan Academician Workstation of Qiu Yong (202005F150038), Yunnan Clinical Center for Bone and joint Diseases (ZX2019-03-04).

基金编号： 2019ZF002 82160417 L-201621 YLXL20170046 2020Y0123 202005F150038 ZX2019-03-04

语种：
外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
JCR分区：
出版当年[2021]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Yunnan, China [2]Kunming Medical University, Yunnan, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Yunnan, China [3]Yunnan Province Stem Cell Technology Application Research Center, Yunnan, China [4]Yunnan Provincial Clinical Medical Center for Bone and Joint Diseases, Yunnan, China [*1]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Yunnan, China.
推荐引用方式(GB/T 7714)：
Wang Weizhou,Wang Yanghao,Tang Zhihong,et al.Mesenchymal stem cells prevent ovariectomy-induced osteoporosis formation in mice through intraosseous vascular remodeling.[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2021,582:64-71.doi:10.1016/j.bbrc.2021.10.033.
APA：
Wang Weizhou,Wang Yanghao,Tang Zhihong,Chen Yongcheng,Liu Zhui...&He Fei.(2021).Mesenchymal stem cells prevent ovariectomy-induced osteoporosis formation in mice through intraosseous vascular remodeling..BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,582,
MLA：
Wang Weizhou,et al."Mesenchymal stem cells prevent ovariectomy-induced osteoporosis formation in mice through intraosseous vascular remodeling.".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 582.(2021):64-71

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