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Curcumin enhances the proliferation and myelinization of Schwann cells through Runx2 to repair sciatic nerve injury.

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Guoliang[1] ; Wang Zhihua[2] ; Gao Shuang[2] ; Wang Yang[1] ; Li Qing[2,*1] ;
机构： [1]Department of Sports Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, PR China. [2]Department of Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, PR China.
出处：
DOI： 10.1016/j.neulet.2021.136391
ISSN：

关键词： Sciatic nerve Curcumin Schwann cells Runx2 Proliferation

摘要：
RUNX Family Transcription Factor 2 (Runx2) promotes neurite outgrowth after sciatic nerve injury, and Curcumin can promote the expression of Runx2. It is worthwhile to explore whether curcumin's repair effect on sciatic nerve injury is related to Runx2.To investigate the repair effect of curcumin on sciatic nerve injury and its possible mechanism.Curcumin improved the sciatic functional index (SFI) and toe spread index (TSI) of rats with sciatic nerve injury and increased the number and diameter of myelinated axons in the sciatic nerve. Curcumin promoted the myelination of SCs (Schwann cells) by increasing the expression of peripheral myelin protein 22 (PMP22), fibrin, S100, and proliferating cell nuclear antige (PCNA). Curcumin treatment increased the proliferation of SCs and the expression of Runx2. Cell experiments further confirmed that curcumin promoted Schwann cell proliferation and myelination through Runx2.Curcumin promotes SCs proliferation and myelination through Runx2 and improves sciatic nerve repair.Copyright © 2021 Elsevier B.V. All rights reserved.

基金：
Yunnan Province Clinical Center for Bone and Joint Diseases (ZX2019-03-04) and the Kunming Medical University Applied Basic Research Joint Special Project [2019FE001 (-034)].

基金编号： ZX2019-03-04 -034

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
JCR分区：
出版当年[2022]版：
Q3 NEUROSCIENCES
最新[2023]版：
Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Sports Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, PR China.
通讯作者：
通讯机构： [2]Department of Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, PR China. [*1]Department of Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, PR China.
推荐引用方式(GB/T 7714)：
Wang Guoliang,Wang Zhihua,Gao Shuang,et al.Curcumin enhances the proliferation and myelinization of Schwann cells through Runx2 to repair sciatic nerve injury.[J].NEUROSCIENCE LETTERS.2022,770:doi:10.1016/j.neulet.2021.136391.
APA：
Wang Guoliang,Wang Zhihua,Gao Shuang,Wang Yang&Li Qing.(2022).Curcumin enhances the proliferation and myelinization of Schwann cells through Runx2 to repair sciatic nerve injury..NEUROSCIENCE LETTERS,770,
MLA：
Wang Guoliang,et al."Curcumin enhances the proliferation and myelinization of Schwann cells through Runx2 to repair sciatic nerve injury.".NEUROSCIENCE LETTERS 770.(2022)

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