机构：[1]Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.医技科室病理科昆明医科大学附属第一医院[2]1997-09, Woman, Han, Breast cancer.[3]1974-07, Woman, Han, Breast cancer.
The spindle assembly checkpoint (SAC) is a highly conserved monitoring system that ensures a fidelity of chromosome segregation during mitosis. Bub3, a mitotic Checkpoint Protein, is a member of the Bub protein family, and an important factor in the SAC. Abnormal expression of Bub3 results in mitotic defects, defective spindle gate function, chromosomal instability and the development of aneuploidy cells. Aneuploidy is a state of abnormal karyotype that has long been considered as a marker of tumorigenesis. Karyotypic heterogeneity in tumor cells, known as "chromosomal instability" (CIN), can be used to distinguish cancerous cells from their normal tissue counterpart. In this review, we summarize the expression and clinical significance of Bub3 in a variety of tumors and suggest that it has potential in the treatment of cancer. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
基金：
Department of Science
and Technology of Yunnan Province-Kunming Medical University
(2019FE001(-063) to Wang, C), Yunnan Health Training Project of High Level
Talents (D2018058 to Wang, C)
第一作者机构：[1]Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.[2]1997-09, Woman, Han, Breast cancer.
通讯作者：
通讯机构：[1]Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.[3]1974-07, Woman, Han, Breast cancer.
推荐引用方式(GB/T 7714)：
Wang Chenyang,Chen Dating,Pan Chenglong,et al.Research progress of Bub3 gene in malignant tumors.[J].CELL BIOLOGY INTERNATIONAL.2022,46(5):673-682.doi:10.1002/cbin.11740.
APA：
Wang Chenyang,Chen Dating,Pan Chenglong&Wang Chunyan.(2022).Research progress of Bub3 gene in malignant tumors..CELL BIOLOGY INTERNATIONAL,46,(5)
MLA：
Wang Chenyang,et al."Research progress of Bub3 gene in malignant tumors.".CELL BIOLOGY INTERNATIONAL 46..5(2022):673-682
