机构：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.[2]University of Chinese Academy of Sciences, Beijing, 100049, China.[3]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.内科科室皮肤科昆明医科大学附属第一医院
Three new lindenane-type sesquiterpenoid dimers, sarcanolides C-E (1-3), were isolated from the roots of Sarcandra glabra. Sarcanolide C (1) possesses a unique decacyclic scaffold with an unusual orthoformate unit. The structures of 1-3 were determined through extensive spectroscopic analysis, while their absolute configurations were determined by comparison of calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1-3 were evaluated for their inhibitory activity against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages. All the isolates displayed a moderate inhibitory effect against NO production with IC50 values in the range of 13.4-17.2 μM, comparable to that of the positive control L-NMMA.
基金：
This work was financially supported by the National Natural
Science Foundation of China (32000280 and U1802287), the
Ten Thousand Talents Plan of Yunnan Province for Industrial
Technology Leading Talents, the Major Biomedical Project of
Yunnan Province (2019ZF010), the State Key Laboratory of
Phytochemistry and Plant Resources in West China (S2017-ZZ08 and P2019-ZZ02), and State Key Laboratory of Functions
and Applications of Medicinal Plants (FAMP201901K).
第一作者机构：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.[2]University of Chinese Academy of Sciences, Beijing, 100049, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xiao Long-Gao,Li Ping,Yan Huan,et al.Sarcanolides C-E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra.[J].ORGANIC & BIOMOLECULAR CHEMISTRY.2022,20(6):1320-1326.doi:10.1039/d1ob02417e.
APA：
Xiao Long-Gao,Li Ping,Yan Huan,Ni Wei,He Li&Liu Hai-Yang.(2022).Sarcanolides C-E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra..ORGANIC & BIOMOLECULAR CHEMISTRY,20,(6)
MLA：
Xiao Long-Gao,et al."Sarcanolides C-E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra.".ORGANIC & BIOMOLECULAR CHEMISTRY 20..6(2022):1320-1326
