机构：[1]Department II of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.外科科室神经外科神经外一科（神经外科）昆明医科大学附属第一医院[2]Pediatric Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.昆明医科大学附属第一医院
DNA topoisomerase II alpha (TOP2A) reportedly plays a crucial role in several cancers, however, the precise regulatory role of TOP2A in metastatic characteristics of glioma is still poorly understood. Herein, we sought to elucidate the mechanisms by which TOP2A affects the metastatic phenotypes of glioma. We observed that a high level of TOP2A expression was dramatically linked with inferior survival in glioma patients while silencing of TOP2A impaired glioma cell proliferation and aggressiveness. TOP2A was found to directly interact with β-catenin and facilitated its translocation into the nucleus. Mechanistically, TOP2A effectively induced glioma cell growth and invasion in a β-catenin-dependent manner. Overall, we pinpoint TOP2A as a critical activator of the Wnt/β-catenin pathway in glioma, promoting cell growth, migration, and invasion.
基金：
The Yunnan Provincial High-level Health and Family Planning Technical Talent Training Fund supports the Yunnan Provincial Health Commission’s Medical Reserve Talent Training Program (No. H-2018054).
第一作者机构：[1]Department II of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department II of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.[*1]II of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, Yunnan, China
推荐引用方式(GB/T 7714)：
Liu Yi,Ma Jun,Song Jiu-Shan,et al.DNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-catenin.[J].BIOENGINEERED.2022,13(2):2207-2216.doi:10.1080/21655979.2021.2023985.
APA：
Liu Yi,Ma Jun,Song Jiu-Shan,Zhou Hai-Ying,Li Jing-Hui...&Zhao He-Xiang.(2022).DNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-catenin..BIOENGINEERED,13,(2)
MLA：
Liu Yi,et al."DNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-catenin.".BIOENGINEERED 13..2(2022):2207-2216
