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Macrophage M1 regulatory diabetic nephropathy is mediated by m6A methylation modification of lncRNA expression.

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机构： [1]Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China [2]Department of Science and Technology, Kunming Medical University, Kunming, Yunnan Province 650500, China [3]Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA 92521, USA [4]Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China [5]Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China

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Immune and inflammatory responses have been identified to play an important role in diabetic nephropathy (DN) (H. Zhou et al. (2021)). It was found that the part of long non-coding RNA (LncRNA) in nephrosis is related to the negative regulation of MicroRNA (miRNA) (C. Gao et al., 2020), which mechanism is unclear; N6-methyladenosine (m6A) is one of the most common mRNA modifications in eukaryotes (Gu et al. (2020)). m6A has been proved in many works of literature can act on the triple helix structure of RNA-DNA and regulate the relationship between lncRNA and specific DNA sites (Fico et al. (2020); Łoboś and Regulska-Ilow (2021); Xu et al. (2021)). Other studies have shown that m6A methylation modification plays a vital role in developing metabolic diseases such as obesity and type 2 diabetes by regulating glucose and lipid metabolism and immune inflammation. In this study, we performed a subgroup analysis of m6A-modified LncRNA expression in the DN transcriptome dataset (LncRNA high-low expression group); the results showed that the presence of Macrophage M1-related lncRNA (LINC00342, LINC00667, and LNC00963) in the process of m6A methylation recognition and metastasis was indirectly related to the downstream demethylase FTO, at the same time, we analyzed the interaction between m6A and RBM15, which is involved in the immune regulation of macrophage M1, and found that there might be a potential interaction between RBM15 and WTAP, which may play a role in regulating the methylation of lncRNA in macrophage M1, the DN was mediated by macrophage M1 immunoreaction of macrophages.Copyright © 2022 Elsevier Ltd. All rights reserved.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区免疫学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区免疫学

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出版当年[2022]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 IMMUNOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 IMMUNOLOGY

影响因子： 3.2 最新[2023版] 3.6 最新五年平均 3.6 出版当年[2022版] 4 出版当年五年平均 4.174 出版前一年[2021版] 3.2 出版后一年[2023版]

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第一作者机构： [1]Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China

通讯作者：

通讯机构： [1]Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China [5]Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China [*1]Department of Nephrology, the First Affiliated Hospital of Kunming Medical University, No.295, Xichang Road, Kunming, Yunnan Province 650032, China. [*2]Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, No.295, Xichang Road, Kunming, Yunnan Province 650032, China.

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