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Dynamics and correlations in multiplex immune profiling reveal persistent immune inflammation in male drug users after withdrawal.

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收录情况： ◇ SCIE ◇ SSCI

作者：
Re Guo-Fen[1,2] * ; Jia Jie[1,2] * ; Xu Yu[1,3] * ; Zhang Zunyue[4] * ; Xie Zhen-Rong[1] ; Kong Deshenyue[1,2] ; Lu Danfeng[1,2] ; Li Yue[1,2] ; Peng Qing-Yan[1,2] ; Yu Juehua[1,2] ; Kuang Yi-Qun[1,2,*1] ; Wang Kun-Hua[1,4,*1] ;
机构： [1]NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650032, China [2]Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [3]Department of Gastrointestinal and Hernia Surgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [4]School of Medicine, Yunnan University, Kunming 650500, China
出处：
DOI： 10.1016/j.intimp.2022.108696
ISSN：

摘要：
Drug withdrawal elicits immune responses that contribute to the development of withdrawal symptoms and relapse. The understanding of the immunologic dynamics after drug withdrawal is limited, precluding the finding of promising immune intervention measures. Here, we performed cytokine and multiplex immune profiling in heroin, methamphetamine (METH) and ephedrine users after withdrawal and identified the correlation between cytokines and other immune parameters. We showed that broad and strong inflammatory responses occurred at the early stage after drug withdrawal, and the inflammatory responses showed a downtrend with the extension of withdrawal time. Notably, immune dysregulation remained through and may last longer than 12 months after withdrawal in heroin and METH users. Our findings suggest that cytokines, immune cells, complement and immunoglobulin form a complex immune network that regulates immune responses after withdrawal. These data provide a reference for future scientific research and drug research and development.Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

基金：
This work was partly supported by the National Natural Science Foundation of China (81660094, 81870458, 81860100), the Fund for Yunling Scholar (YLXL20170002), the Yunnan Fundamental Research Projects (202101AT070852), the Project for Innovation Team of Department of Science and Technology of Yunnan Province, China (2018HC005), the Fund of Department of Education of Yunnan Province, China (2019Y0352), the Yunnan Provincial Clinical Research Center for Skin Immune Diseases (2019ZF012) from Science and Technology Department of Yunnan Province, the Fund for Digitalization, Development and Application of Biotic Resource (202002AA100007), and the fund of Central public welfare research institute (2019PT310003).
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
JCR分区：
出版当年[2022]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650032, China [2]Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
共同第一作者：
通讯作者：
通讯机构： [1]NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650032, China [2]Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [4]School of Medicine, Yunnan University, Kunming 650500, China [*1]NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650032, China.
推荐引用方式(GB/T 7714)：
Re Guo-Fen,Jia Jie,Xu Yu,et al.Dynamics and correlations in multiplex immune profiling reveal persistent immune inflammation in male drug users after withdrawal.[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2022,107:108696.doi:10.1016/j.intimp.2022.108696.
APA：
Re Guo-Fen,Jia Jie,Xu Yu,Zhang Zunyue,Xie Zhen-Rong...&Wang Kun-Hua.(2022).Dynamics and correlations in multiplex immune profiling reveal persistent immune inflammation in male drug users after withdrawal..INTERNATIONAL IMMUNOPHARMACOLOGY,107,
MLA：
Re Guo-Fen,et al."Dynamics and correlations in multiplex immune profiling reveal persistent immune inflammation in male drug users after withdrawal.".INTERNATIONAL IMMUNOPHARMACOLOGY 107.(2022):108696

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