个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 自然指数

作者：
Zunpeng Liu[1,6] ; Qianzhao Ji[2,6] ; Jie Ren[4,5,6,9] ; Pengze Yan[2,6] ; Zeming Wu[2,6] ; Si Wang[3,7] ; Liang Sun[12,13] ; Zehua Wang[1,6] ; Jiaming Li[4,6,9] ; Guoqiang Sun[1,6] ; Chuqian Liang[2,6] ; Run Sun[1,6] ; Xiaoyu Jiang[2,6] ; Jianli Hu[4,6] ; Yingjie Ding[4,6] ; Qiaoran Wang[4,6,9] ; Shijia Bi[1,6] ; Gang Wei[14] ; Gang Cao[15,16] ; Guoguang Zhao[3,10] ; Hongmei Wang[1,5,6,8] ; Qi Zhou[1,5,6,8] ; Juan Carlos Izpisua Belmonte[11] ; Jing Qu[1,5,6,8] ; Weiqi Zhang[4,5,6,9] ; Guang-Hui Liu[2,3,5,6,8] ;
机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [4]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [5]Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China [7]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [8]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [9]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, China [10]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [11]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, San Diego, CA 92037, USA [12]NHC Beijing Institute of Geriatrics, NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine of Chinese Academy of Medical Sciences, National Center of Gerontology/ Beijing Hospital, Beijing 100730, China [13]Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [14]CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China [15]State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China [16]Bio-Medical Center, Huazhong Agricultural University, Wuhan 430070, China
出处：
DOI： 10.1016/j.devcel.2022.05.004
ISSN：

摘要：
Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be associated with the erosion of chromatin organization at the nuclear periphery. However, how such gradual changes in higher-order genome organization impinge on local epigenetic modifications to drive cellular mechanisms of aging has remained enigmatic. Here, through large-scale epigenomic analyses of isogenic young, senescent, and progeroid human mesenchymal progenitor cells (hMPCs), we delineate a hierarchy of integrated structural state changes that manifest as heterochromatin loss in repressive compartments, euchromatin weakening in active compartments, switching in interfacing topological compartments, and increasing epigenetic entropy. We found that the epigenetic de-repression unlocks the expression of pregnancy-specific beta-1 glycoprotein (PSG) genes that exacerbate hMPC aging and serve as potential aging biomarkers. Our analyses provide a rich resource for uncovering the principles of epigenomic landscape organization and its changes in cellular aging and for identifying aging drivers and intervention targets with a genome-topology-based mechanism.Copyright © 2022 Elsevier Inc. All rights reserved.

基金：
National Key Research and Development Program of China (2020YFA0804000), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16010000), the National Key Research and Development Program of China (2018YFC2000100, 2018YFA0107203, 2021YFF1201005, 2020YFA0803401, 2019YFA0802202, and 2021ZD0202401), the National Natural Science Foundation of China (81921006, 92149301, 92168201, 82125011, 91949209, 92049304, 92049116, 32100937, 81861168034, 82071588, 82122024, 32121001, 82192863, 81870228, 81922027, 31900523, 31970597, 81901432, and 91849132), Beijing Natural Science Foundation (Z190019), the Key Research Program of the Chinese Academy of Sciences (KFZD-SW-221), K.C. Wong Education Foundation (GJTD-2019-06 and GJTD-2019-08), the Informatization Plan of Chinese Academy of Sciences (CAS-WX2021SF-0301), Youth Innovation Promotion Association of CAS (E1CAZW0401), the Tencent Foundation (2021-1045), the Milky Way Research Foundation (MWRF), the State Key Laboratory of Stem Cell and Reproductive Biology, the State Key Laboratory of Membrane Biology,CASProject for Young Scientists in Basic Research (YSBR-012), CAS Special Research Assistant (SRA) Program, Young Elite Scientists Sponsorship Program by CAST (no.YESS20200012), the Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes (11000022T000000461062), Priority Union Foundation of Yunnan Provincial Science and Technology Department (202001AY070001-011), and Innovation project of CAMS (2021- I2M-1-050).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学 1 区 发育生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学 1 区 发育生物学
JCR分区：
出版当年[2022]版：
Q1 CELL BIOLOGY Q1 DEVELOPMENTAL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY Q1 DEVELOPMENTAL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [4]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [5]Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China [8]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [9]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式(GB/T 7714)：
Zunpeng Liu,Qianzhao Ji,Jie Ren,et al.Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging.[J].DEVELOPMENTAL CELL.2022,57(11):1347-+.doi:10.1016/j.devcel.2022.05.004.
APA：
Zunpeng Liu,Qianzhao Ji,Jie Ren,Pengze Yan,Zeming Wu...&Guang-Hui Liu.(2022).Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging..DEVELOPMENTAL CELL,57,(11)
MLA：
Zunpeng Liu,et al."Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging.".DEVELOPMENTAL CELL 57..11(2022):1347-+

资源点击量：53661 今日访问量：0 总访问量：1665 更新日期：2024-11-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 昆明医科大学第一附属医院 技术支持：重庆聚合科技有限公司 地址：云南省昆明市西昌路295号(650032)