研究单位：[1]Nanjing Medical University[2]Beijing Anzhen Hospital[3]Beijing Fuwai Hospital Chinese Academy of Medical Sciences,Beijing,Beijing,China[4]Chongqing Hospital of Jiangsu Provincial People''s Hospital,Chongqing,Chongqing,China[5]Guangdong Provincial People''s Hospital,Guangzhou,Guangdong,China[6]The First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi,China[7]The Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,China[8]Suqian Hospital of of Nanjing Medical University,Suqian,Jiangsu,China[9]Subei People''s Hospital of Jiangsu Province,Yangzhou,Jiangsu,China,225001[10]the Second Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,China,300088[11]Qilu Hospital of Shandong University,Jinan,Shandong,China,250012[12]Shanghai DeltaHealth Hospital,Shanghai,Shanghai,China[13]Shanxi Cardiovascular Hospital,Taiyuan,Shanxi,China[14]West China Hospital of Sichuan University,Chengdu,Sichuan,China[15]The Friendship Hospital of Yili Kazak Autonomous Prefecture,Kazak,Xinjiang,China[16]The Seventh Affiliated Hospital of Xinjiang Medical University,Urumchi,Xinjiang,China[17]The First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,China[18]Beijing Anzhen Hospital Capital Medical University,Beijing,China[19]Beijing Chaoyang Hospital,Beijing,China[20]the First Affiliated Hospital of Bengbu Medical College,Bengbu,China[21]Xiangya Hospital Central South University,Changsha,China[22]The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,China[23]the First Affiliated Hospital of Guilin Medical College,Guilin,China[24]The First Affiliated Hospital of Nanjing Medical University,Nanjing,China,210029[25]Nanjing First Hospital, Nanjing Medical University,Nanjing,China[26]the Affiliated Hospital of Qingdao University,Qingdao,China[27]Shanghai East Hospital Tongji University,Shanghai,China[28]the First Affiliated Hospital of Shantou University Medical College,Shantou,China[29]Teda International Cardiovascular Hospital,Tianjin,China[30]Tianjin Chest Hospital,Tianjin,China[31]Xiamen Cardiovascular Hospital,Xiamen,China
Acute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity. Understanding the inflammatory responses and inflammation resolutions is essential for an appropriate management of AAS. Twenty Chinese cardiovascular centers have collaborated to create a multicenter observational registry (named Chinese registry of Additive Anti-inflammatory Action for Aortopathy & Arteriopathy [5A]), with consecutive enrollment of adult patients who underwent surgery for AAS that was started on Jan 1, 2016 and will be ended on December 31, 2040. Specially, the impact of inflammation and anti-inflammatory strategies on the early and late adverse events are investigated. Primary outcomes are severe systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), Sequential Organ Failure Assessment (SOFA) scores at 7 days following this current surgery. Secondary outcomes are SISR, 30-day mortality, operative mortality, hospital mortality, new-onset stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.
