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A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

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研究单位： [1]Celgene [2]Local Institution - 0366,Los Alamitos,California,United States,90720 [3]Sharp Memorial Hospital,San Diego,California,United States,92123 [4]Private Practice - Dr. James R. Berenson,West Hollywood,California,United States,90069 [5]Local Institution - 0381,Aurora,Colorado,United States,80045 [6]Local Institution - 0380,Farmington,Connecticut,United States,06030 [7]Advanced Research,Tamarac,Florida,United States,33321 [8]University Cancer Blood Ctr,Athens,Georgia,United States,30607 [9]Local Institution - 0048,Marietta,Georgia,United States,30060 [10]Central Care Cancer Center - Garden City,Garden City,Kansas,United States,67846 [11]University of Kansas Medical Center,Westwood,Kansas,United States,66205 [12]Local Institution - 0358,Baton Rouge,Louisiana,United States,70808 [13]Tulane Cancer Center,New Orleans,Louisiana,United States,70112 [14]Sinai Hospital Of Baltimore,Baltimore,Maryland,United States,21215 [15]Dana-Farber Cancer Institute,Boston,Massachusetts,United States,02215 [16]University of Michigan,Ann Arbor,Michigan,United States,48109 [17]Local Institution - 0364,Detroit,Michigan,United States,48202 [18]Hattiesburg Clinic Hematology/Oncology,Hattiesburg,Mississippi,United States,39401 [19]Local Institution - 0242,Jackson,Mississippi,United States,39213 [20]Astera Cancer Care,East Brunswick,New Jersey,United States,08816 [21]Local Institution - 0363,Ridgewood,New Jersey,United States,07450 [22]University of New Mexico Comprehensive Cancer Center,Albuquerque,New Mexico,United States,87131 [23]Local Institution - 0372,Bronx,New York,United States,10469 [24]Local Institution - 0245,Buffalo,New York,United States,14215 [25]Northwell Health/ RJ Zuckerberg Cancer Center,Lake Success,New York,United States,11042 [26]Local Institution - 0373,New Hyde Park,New York,United States,11042 [27]Local Institution - 0371,New York,New York,United States,10028 [28]Rochester General Hospital,Rochester,New York,United States,14621 [29]Local Institution - 0374,Shirley,New York,United States,11967 [30]Local Institution - 0274,Williamsville,New York,United States,14221 [31]Duke Cancer Institute,Durham,North Carolina,United States,27710 [32]Local Institution - 0377,Cleveland,Ohio,United States,44111 [33]Cleveland Clinic,Cleveland,Ohio,United States,44195 [34]Local Institution - 0376,Mayfield Heights,Ohio,United States,44124 [35]Local Institution - 0359,Allentown,Pennsylvania,United States,18103 [36]Local Institution - 0264,York,Pennsylvania,United States,17403 [37]The West Clinic, PLLC dba West Cancer Center,Germantown,Tennessee,United States,38138 [38]Local Institution - 0378,Abilene,Texas,United States,79606 [39]University of Texas MD Anderson Cancer Center,Houston,Texas,United States,77030 [40]Mays Cancer Center,San Antonio,Texas,United States,78229 [41]Utah Cancer Specialists,Salt Lake City,Utah,United States,84106 [42]Hematology Oncology Associates of Fredericksburg,Fredericksburg,Virginia,United States,22408 [43]VA Puget Sound Health Care System,Seattle,Washington,United States,98108 [44]Local Institution - 0293,Seattle,Washington,United States,98109 [45]Local Institution - 0097,Spokane,Washington,United States,99208 [46]Local Institution - 0220,Madison,Wisconsin,United States,53792 [47]Sanatorio Chivilcoy,Chivilcoy,Buenos Aires,Argentina,6620 [48]Hospital Privado Universitario de Córdoba,Cordoba,Córdoba,Argentina,5016 [49]Clinica Viedma S. A,Viedma,Río Negro,Argentina,R8500ACE [50]Hospital Privado de Rosario,Rosario,Santa Fe,Argentina,2000 [51]Centro Mdico ""Barrio Parque"",Buenos Aires,Argentina,1425 [52]" Hospital Británico de Buenos Aires,Buenos Aires,Argentina,CP1280AEB [53]Clínica de Nefrología, Urología y Enfermedades Cardiovasculares,Santa Fe,Argentina,3000 [54]Liverpool Hospital,Liverpool,New South Wales,Australia,2170 [55]Calvary Mater Newcastle,Waratah,New South Wales,Australia,2298 [56]Wollongong Hospital-Illawarra Cancer Care Centre,Wollongong,New South Wales,Australia,2500 [57]Sunshine Coast University Hospital,Birtinya,Queensland,Australia,4575 [58]Box Hill Hospital,Box Hill,Victoria,Australia,3128 [59]The Alfred Hospital,Melbourne,Victoria,Australia,3004 [60]First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,China,650032

关键词： Multiple myeloma RRMM MeziVd PVd CC92480 pomalidomide bortezomib dexamethasone mezigdomide

研究目的：

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.