Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus
研究单位：[1]AbbVie[2]Arizona Arthritis & Rheumatology Associates, P.C. /ID# 254767,Flagstaff,Arizona,United States,86001-6269[3]Arizona Arthritis & Rheumatology Research, PLLC /ID# 252820,Gilbert,Arizona,United States,85297-7336[4]Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 252824,Glendale,Arizona,United States,85306-9802[5]AZ Arthritis and Rheumotology Research, PLLC /ID# 252831,Phoenix,Arizona,United States,85032-9306[6]Arizona Arthritis & Rheumatology Research, PLLC /ID# 252825,Phoenix,Arizona,United States,85037[7]Arizona Arthritis & Rheumatology Associates - Tucson /ID# 252828,Tucson,Arizona,United States,85704[8]David S. Hallegua MD, A Professional Corporation /ID# 253902,Beverly Hills,California,United States,90211[9]Wallace Rheumatic Studies Center, LLC /ID# 252806,Beverly Hills,California,United States,90211[10]Providence Medical Foundation /ID# 252822,Fullerton,California,United States,92835[11]Newport Huntington Medical Group /ID# 252827,Huntington Beach,California,United States,92648-5994[12]Irvine Clinical Research /ID# 254062,Irvine,California,United States,92614[13]Moores Cancer Center at UC San Diego /ID# 253903,La Jolla,California,United States,92093[14]Providence St. John''s Health Center /ID# 253905,Santa Monica,California,United States,90404-2303[15]Millennium Clinical Trials /ID# 252817,Thousand Oaks,California,United States,91360-3951[16]Denver Arthritis Clinic /ID# 253189,Denver,Colorado,United States,80230[17]Arthritis & Rheumatic Disease Specialties /ID# 253624,Aventura,Florida,United States,33180[18]HARAC Research Corp. /ID# 254922,Avon Park,Florida,United States,33825-2958[19]Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 253623,Boca Raton,Florida,United States,33486[20]Bay Area Arthritis and Osteo /ID# 253597,Brandon,Florida,United States,33511[21]Clinical Research of West Florida, Inc /ID# 253899,Clearwater,Florida,United States,33765[22]Believe Clinical Trials /ID# 255427,Coral Springs,Florida,United States,33065[23]International Medical Research - Daytona /ID# 253617,Daytona Beach,Florida,United States,32117[24]Omega Research Debary, LLC /ID# 254939,DeBary,Florida,United States,32713-2260[25]Sweet Hope Research Specialty Inc /ID# 253614,Hialeah,Florida,United States,33016-1897[26]UF Health Rheumatology /ID# 255351,Jacksonville,Florida,United States,32256[27]Lakes Research, LLC /ID# 253621,Miami,Florida,United States,33014[28]HMD Research LLC /ID# 253595,Orlando,Florida,United States,32819[29]Millennium Research /ID# 253600,Ormond Beach,Florida,United States,32174[30]IRIS Research and Development, LLC /ID# 253618,Plantation,Florida,United States,33324[31]Clinical Research of West Florida - Tampa /ID# 253602,Tampa,Florida,United States,33606-1246[32]BayCare Medical Group, Inc. /ID# 255135,Tampa,Florida,United States,33614-7101[33]Atlanta Research Center for Rheumatology /ID# 253610,Marietta,Georgia,United States,20060[34]Crowley CORE, LLC - Hinsdale Orthopaedics /ID# 253018,Hinsdale,Illinois,United States,60521-3186[35]OrthoIllinois /ID# 253188,Rockford,Illinois,United States,61114-4937[36]Greater Chicago Specialty Physicians /ID# 253021,Schaumburg,Illinois,United States,60195-3106[37]Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 253020,Skokie,Illinois,United States,60076[38]Northshore University Health System Dermatology Clinical Trials Unit /ID# 254568,Skokie,Illinois,United States,60077[39]Deerbrook Medical Associates /ID# 253029,Vernon Hills,Illinois,United States,60061[40]Western KY Rheumatology, PLLC /ID# 254937,Hopkinsville,Kentucky,United States,42240[41]Rheumatology Associates PA - Portland /ID# 254933,Portland,Maine,United States,04102-2643[42]AA Medical Research Center - Grand Blanc /ID# 253028,Grand Blanc,Michigan,United States,48439[43]June DO, PC /ID# 253030,Lansing,Michigan,United States,48910[44]The Center for Rheumatic Disease (KCPP) North /ID# 254786,Kansas City,Missouri,United States,64151[45]Logan Health Research /ID# 252808,Kalispell,Montana,United States,59901[46]Dartmouth-Hitchcock Medical Center /ID# 254923,Lebanon,New Hampshire,United States,03756[47]NM Clinical Research & Osteoporosis Center, Inc /ID# 254123,Albuquerque,New Mexico,United States,87106[48]Arthritis and Osteo Assoc /ID# 252818,Las Cruces,New Mexico,United States,88011[49]NYU Langone Ambulatory Care Brooklyn Heights /ID# 253592,Brooklyn,New York,United States,11201[50]NYU Langone Orthopedic Center /ID# 253613,New York,New York,United States,10016-2772[51]DJL Clinical Research, PLLC /ID# 253620,Charlotte,North Carolina,United States,28211[52]PMG Research of Salisbury /ID# 253608,Salisbury,North Carolina,United States,28144[53]Wake Forest Baptist Health /ID# 254125,Winston-Salem,North Carolina,United States,27157[54]Trinity Health Med Arts Clinic /ID# 253031,Minot,North Dakota,United States,58701[55]Paramount Medical Research Con /ID# 253016,Middleburg Heights,Ohio,United States,44130[56]Clinical Research of Philadelphia, LLC /ID# 254156,Philadelphia,Pennsylvania,United States,19114[57]West Tennessee Research Institute /ID# 252807,Jackson,Tennessee,United States,38305[58]Arthritis and Rheumatology Research Institute, PLLC /ID# 253014,Allen,Texas,United States,75013-6147[59]JPS Rheumatology Clinic /ID# 253185,Fort Worth,Texas,United States,76104-4917[60]R & H Clinical Research - 777 Katy /ID# 254126,Katy,Texas,United States,77450-2244[61]Biopharma Informatic - McAllen /ID# 253022,McAllen,Texas,United States,78503-1527[62]Trinity Universal Research Associates, Inc /ID# 253013,Plano,Texas,United States,75024-5283[63]Advanced Rheumatology of Houston /ID# 253024,The Woodlands,Texas,United States,77382[64]DM Clinical Research - Tomball /ID# 255134,Tomball,Texas,United States,77375[65]Advanced Research Institute - Ridgeline /ID# 254152,Ogden,Utah,United States,84405-6779[66]Carilion Clinic /ID# 253374,Roanoke,Virginia,United States,24016[67]Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich /ID# 254278,Ciudad Autonoma Buenos Aires,Buenos Aires,Argentina,1426[68]Hospital Italiano La Plata /ID# 254284,La Plata,Buenos Aires,Argentina,1902[69]CER Instituto Medico /ID# 255302,Quilmes,Buenos Aires,Argentina,1878[70]Aprillus Asistencia e Investigacion /ID# 254276,Ciudad Autonoma de Buenos Aire,Ciuadad Autonoma De Buenos Aires,Argentina,1046[71]Fundacion CIDEA /ID# 254279,Ciudad Autonoma de Buenos Aire,Ciuadad Autonoma De Buenos Aires,Argentina,1121[72]Sanatorio Guemes /ID# 254283,Ciudad Autonoma de Buenos Aire,Ciuadad Autonoma De Buenos Aires,Argentina,1180[73]Instituto CAICI S.R.L /ID# 254280,Rosario,Santa Fe,Argentina,2000[74]Centro de Investigaciones Medicas Tucuman /ID# 254274,San Miguel de Tucuman,Tucuman,Argentina,4000[75]Holdsworth House Medical Practice /ID# 253542,Darlinghurst,New South Wales,Australia,2010[76]Royal Brisbane and Women''s Hospital /ID# 253828,Herston,Queensland,Australia,4029[77]UZ Brussel /ID# 253866,Jette,Bruxelles-Capitale,Belgium,1090[78]UCL Saint-Luc /ID# 253113,Woluwe-Saint-Lambert,Bruxelles-Capitale,Belgium,1200[79]ZNA - Jan Palfijn /ID# 252802,Merksem,Belgium,2170[80]University Clinical Centre of the Republic of Srpska /ID# 253581,Banja Luka,Republika Srpska,Bosnia and Herzegovina,78000[81]University Clinical Centre of the Republic of Srpska /ID# 253582,Banja Luka,Republika Srpska,Bosnia and Herzegovina,78000[82]University Clinical Center Tuzla /ID# 253639,Tuzla,Tuzlanski,Bosnia and Herzegovina,75000[83]Clinical Center University of Sarajevo /ID# 253583,Sarajevo,Bosnia and Herzegovina,71000[84]SER - Serviços Especializados em Reumatologia da Bahia /ID# 253354,Salvador,Bahia,Brazil,40150-150[85]CEDOES - Pesquisa e Diagnóstico /ID# 254588,Vitoria,Espirito Santo,Brazil,29055-450[86]CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 253346,Juiz de For a,Minas Gerais,Brazil,36010-570[87]EDUMED Educacao em Saude S/S L /ID# 253274,Curitiba,Parana,Brazil,80440-080[88]Hospital de Clinicas de Porto Alegre /ID# 253357,Porto Alegre,Rio Grande Do Sul,Brazil,90035-903[89]LMK Sevicos Medicos S/S /ID# 253353,Porto Alegre,Rio Grande Do Sul,Brazil,90480-000[90]Hospital do Rim /ID# 253983,Sao Paulo,Brazil,04038-002[91]Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo /ID# 254316,Sao Paulo,Brazil,05403-000[92]Medical Center Academy /ID# 253322,Sofiya,Sofia,Bulgaria,1612[93]UMHAT Kaspela EOOD /ID# 252645,Plovdiv,Bulgaria,4001[94]"""Medical Center Artmed"" Ltd /Id# 254572,Plovdiv,Bulgaria,4002[95]"
Medical center Unimed /ID# 253324,Plovdiv,Bulgaria,4023[96]Medical center Teodora /ID# 252646,Ruse,Bulgaria,7012[97]Diagnostic consultative center Focus-5 /ID# 252642,Sofia,Bulgaria,1463[98]Diagnostic consultative center Focus-5 /ID# 252643,Sofia,Bulgaria,1463[99]Military Medical Academy Multiprofile Hospital /ID# 252644,Sofia,Bulgaria,1606[100]Centro Internacional de Estudios Clinicos /ID# 254838,Santiago,Chile,8420383[101]The first affiliated hospital of bengbu medical college /ID# 252853,Bengbu,Anhui,China,233004[102]Anhui Provincial Hospital /ID# 253041,Hefei,Anhui,China,230001[103]Peking University Third Hospital /ID# 253138,Beijing,Beijing,China,100191[104]Peking Union Medical College Hospital /ID# 253045,Beijing,Beijing,China,100730[105]The First Affiliated Hospital of Xiamen University /ID# 252630,Xiamen,Fujian,China,361003[106]Guangdong Provincial People''s Hospital /ID# 252920,Guangzhou,Guangdong,China,510080[107]The First Affiliated Hospital, Sun Yat-sen University /ID# 252921,Guangzhou,Guangdong,China,510080[108]Sun Yat-sen Memorial Hospital of Sun Yat-sen University /ID# 253137,Guangzhou,Guangdong,China,510120[109]The First Affiliated Hospital of Guangzhou Medical University /ID# 252927,Guangzhou,Guangdong,China,510163[110]The Third Affiliated Hospital, Sun Yat-Sen University /ID# 252923,Guangzhou,Guangdong,China,510630[111]The First Affiliated Hospital of Shantou University Medical College /ID# 253426,Shantou,Guangdong,China,515041[112]Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 252963,Wuhan,Hubei,China,430022[113]Tongji Hospital Tongji Medical College of HUST /ID# 252632,Wuhan,Hubei,China,430030[114]Zhuzhou Central Hospital /ID# 252962,Zhuzhou,Hunan,China,412007[115]The Affiliated Hospital of Inner Mongolia Medical University /ID# 252629,Huhehaote,Inner Mongolia,China,010050[116]The First People''s Hospital of Changzhou /ID# 252992,Changzhou,Jiangsu,China,213003[117]Nanjing Drum Tower Hospital /ID# 253042,Nanjing,Jiangsu,China,210008[118]Wuxi People''s Hospital /ID# 253858,Wuxi,Jiangsu,China,214023[119]Xuzhou Central Hospital /ID# 252922,Xuzhou,Jiangsu,China,221009[120]Yancheng First People''s Hospital /ID# 254599,Yancheng,Jiangsu,China,224001[121]The First People''s Hospital of Jiujiang /ID# 252989,Jiujiang,Jiangxi,China,332000[122]Jiangxi Pingxiang People''s Hospital /ID# 252919,Pingxiang,Jiangxi,China,337055[123]The First Hospital of Jilin University /ID# 252771,Changchun,Jilin,China,130021[124]The Second Affiliated Hospital of Xi''an Jiaotong University /ID# 252861,Xi''an,Shaanxi,China,710004[125]Jining No.1 People''s Hospital /ID# 252897,Jining,Shandong,China,272001[126]Linyi People''s Hospital /ID# 252898,Linyi,Shandong,China,276034[127]The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 252633,Hangzhou,Zhejiang,China,310006[128]Zhejiang Province People''s Hospital /ID# 253860,Hangzhou,Zhejiang,China,310014[129]The First Affiliated Hospital of Wenzhou Medical University /ID# 253649,Wenzhou,Zhejiang,China,325000[130]China-Japan Friendship Hosp /ID# 253048,Beijing,China,100029[131]First Affiliated Hospital of Kunming Medical University /ID# 252925,Kunming,China,650032[132]Jiangxi Provincial People''s Hospital /ID# 252940,Nanchang,China,330006[133]Affiliated hospital of nantong university /ID# 252991,Nantong,China,226001[134]Tianjin Medical University General Hospital /ID# 252868,Tianjin,China,300052[135]Northern Jiangsu People''s Hospital /ID# 252945,Yangzhou,China,225001[136]Hospital Pablo Tobon Uribe /ID# 254101,Medellín,Antioquia,Colombia,50034[137]Centro de Investigacion en Reumatologia y Especialidades Medicas- CIREEM SAS /ID# 254097,Bogota,Cundinamarca,Colombia,110221[138]Healthy Medical Center SAS /ID# 254098,Zipaquira,Cundinamarca,Colombia,250252[139]Fundacion Oftalmologica de Santander - FOSCAL /ID# 254100,Floridablanca,Santander,Colombia,681004[140]Klinicki bolnicki centar Osijek /ID# 252847,Osijek,Osjecko-baranjska Zupanija,Croatia,31000[141]Klinicki bolnicki centar Rijeka /ID# 252848,Rijeka,Primorsko-goranska Zupanija,Croatia,51000[142]Klinicki bolnicki centar Split /ID# 252849,Split,Splitsko-dalmatinska Zupanija,Croatia,21000[143]Poliklinika Solmed /ID# 252965,Grad Zagreb,Croatia,10000[144]Poliklinika Bonifarm /ID# 252846,Zagreb,Croatia,10000[145]Innomedica /ID# 253722,Tallinn,Harjumaa,Estonia,10117[146]East Tallinn Central Hospital /ID# 253721,Tallinn,Harjumaa,Estonia,11312[147]MediTrials /ID# 253720,Tartu,Tartumaa,Estonia,50708[148]North Estonia Medical Centre /ID# 253723,Tallinn,Estonia,13419[149]CHU Toulouse - Hopital Purpan /ID# 254148,TOULOUSE Cedex 9,Haute-Garonne,France,31059[150]HCL - Hopital de la Croix-Rousse /ID# 254147,Lyon,Rhone,France,69004[151]Hopital Pitie Salpetriere /ID# 253009,Paris,France,75013[152]Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 252976,Kiel,Schleswig-Holstein,Germany,24105[153]Immanuel Krankenhaus Berlin /ID# 253389,Berlin-buch,Germany,13125[154]ISA Interdisciplinary Study Association GmbH /ID# 253391,Berlin,Germany,10789[155]Krankenhaus Porz am Rhein /ID# 254373,Cologne,Germany,51149[156]Fraunhofer Institute for Translational Medicine & Pharmacology ITMP /ID# 253734,Frankfurt am Main,Germany,60596[157]General Hospital of Athens Laiko /ID# 252952,Athens,Attiki,Greece,11527[158]University General Hospital Attikon /ID# 253209,Athens,Attiki,Greece,12462[159]University General Hospital of Heraklion PA.G.N.I /ID# 252951,Heraklion,Kriti,Greece,71500[160]Debreceni Egyetem Klinikai Kozpont /ID# 252877,Debrecen,Hajdu-Bihar,Hungary,4032[161]Vital Medical Center Orvosi es Fogaszati Kozpont /ID# 252876,Veszprém,Veszprem,Hungary,8200[162]Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Ist /ID# 254293,Budapest,Hungary,1097[163]Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz /ID# 252886,Gyula,Hungary,5700[164]Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 254552,Pecs,Hungary,7624[165]The Chaim Sheba Medical Center /ID# 252857,Ramat Gan,Tel-Aviv,Israel,5265601[166]Tel Aviv Sourasky Medical Center /ID# 252858,Tel Aviv-Yafo,Tel-Aviv,Israel,6423906[167]Hadassah Medical Center-Hebrew University /ID# 252654,Jerusalem,Yerushalayim,Israel,91120[168]The Lady Davis Carmel Medical Center /ID# 253303,Haifa,Israel,34362[169]Meir Medical Center /ID# 254187,Kfar Saba,Israel,4428164[170]Galilee Medical Center /ID# 252859,Nahariya,Israel,2210001[171]Azienda Ospedaliera San Camillo Forlanini /ID# 253680,Rome,Lazio,Italy,00152[172]Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 254288,Rome,Lazio,Italy,00161[173]Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 254138,Ancona,Italy,60126[174]Azienda Ospedaliera di Padova /ID# 253704,Padova,Italy,35128[175]Azienda Ospedaliero Universitaria Pisana-Stabilimento di Santa Chiara /ID# 254289,Pisa,Italy,56126[176]National Hospital Organization Chibahigashi National Hospital /ID# 253268,Chiba-shi,Chiba,Japan,260-8712[177]Hospital of the University of Occupational and Environmental Health, Japan /ID# 253269,Kitakyushu-shi,Fukuoka,Japan,807-8556[178]Hokkaido University Hospital /ID# 253306,Sapporo-shi,Hokkaido,Japan,060-8648[179]Tohoku University Hospital /ID# 253267,Sendai-shi,Miyagi,Japan,9808574[180]University of Miyazaki Hospital /ID# 253416,Miyazaki-shi,Miyazaki,Japan,889-1692[181]Okayama University Hospital /ID# 253821,Okayama-shi,Okayama,Japan,700-8558[182]Shinkenko Clinic /ID# 253271,Naha-shi,Okinawa,Japan,900-0015[183]Saitama Medical Center /ID# 253263,Kawagoe-shi,Saitama,Japan,350-8550[184]Tokyo Medical And Dental University Hospital /ID# 254430,Bunkyo-ku,Tokyo,Japan,113-8519[185]University of Yamanashi Hospital /ID# 253264,Chuo-shi,Yamanashi,Japan,409-3821[186]SoonChunHyang University CheonAn Hospital /ID# 254777,Cheonan-si,Chungcheongnamdo,Korea, Republic of,31151[187]Chonnam National University Bitgoeul Hospital /Id# 254675,Gwangju-Gwangyeoksi,Gwangju Gwang Yeogsi,Korea, Republic of,61748[188]Hanyang University Seoul Hospital /ID# 252955,Seoul,Seoul Teugbyeolsi,Korea, Republic of,04763[189]Asan Medical Center /ID# 254022,Seoul,Korea, Republic of,05505[190]The Catholic University of Korea, Seoul St. Mary''s Hospital /ID# 252958,Seoul,Korea, Republic of,06591[191]M & M Centrs LTD /ID# 253752,Adazi,Latvia,LV-2164[192]Daugavpils Regional Hospital /ID# 253754,Daugavpils,Latvia,LV-5417[193]Pauls Stradins Clinical University Hospital /ID# 253750,Riga,Latvia,LV- 1002[194]Riga East Clinical University Hospital /ID# 253751,Riga,Latvia,LV-1079[195]Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 253755,Kaunas,Lithuania,50161[196]Republic Klaipeda Hospital /ID# 253759,Klaipeda,Lithuania,92231[197]Inlita Santara CTC /ID# 253758,Vilnius,Lithuania,08406[198]Vilnius University Hospital Santaros Klinikos /ID# 253756,Vilnius,Lithuania,08661[199]CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 253965,Mexico City,Ciudad De Mexico,Mexico,11850[200]Morales Vargas Centro de Investigacion S.C. /ID# 254661,Leon,Guanajuato,Mexico,37000[201]Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 253966,Guadalajara,Jalisco,Mexico,44650[202]Unidad de Investigacion de las Enfermedades Reumatologicas SA de CV /ID# 255146,Mexico City,Mexico,06090[203]Middlemore Clinical Trials /ID# 253555,Papatoetoe,Auckland,New Zealand,2025[204]North Shore Hospital /ID# 253554,Takapuna,Auckland,New Zealand,0622[205]MICS Centrum Medyczne Bydgoszcz /ID# 253281,Bydgoszcz,Kujawsko-pomorskie,Poland,85-065[206]Szpital Uniwersytecki nr 2 im. Dr. Jana Biziela /ID# 253233,Bydgoszcz,Kujawsko-pomorskie,Poland,85-168[207]ETYKA-Osrodek Badan Klinicznych /ID# 252967,Olsztyn,Warminsko-mazurskie,Poland,10-117[208]Ortopedyczno-Rehabilitacyjny Szpital Kliniczny im. Wiktora Degi /ID# 252964,Poznan,Wielkopolskie,Poland,61-545[209]MICS Centrum Medyczne Warszawa /ID# 253273,Warsaw,Poland,00-874[210]Centro Hospitalar do Tamega e Sousa - Hospital Padre Americo /ID# 252911,Guilhufe,Porto,Portugal,4560-136[211]Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 252902,Ponte de Lima,Viana Do Castelo,Portugal,4990-041[212]Hospital Garcia de Orta, EPE /ID# 252903,Almada,Portugal,2805-267[213]Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 252899,Porto,Portugal,4099-001[214]GCM Medical Group PSC /ID# 253039,San Juan,Puerto Rico,00917-3104[215]Caribbean Medical Research Center /ID# 254882,San Juan,Puerto Rico,00918-3501[216]Mindful Medical Research /ID# 253040,San Juan,Puerto Rico,00918-3756[217]Spitalul Clinic Judetean de Urgenta Cluj -Napoca /ID# 252904,Cluj-Napoca,Cluj,Romania,400006[218]Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL /ID# 253207,Brasov,Romania,500283[219]Spitalul Clinic Sf. Maria /ID# 252905,Bucuresti,Romania,011172[220]Spitalul Clinic Sf. Maria /ID# 254318,Bucuresti,Romania,011172[221]Institute for Rheumatology /ID# 253172,Belgrade,Beograd,Serbia,11000[222]Institute for Rheumatology /ID# 253173,Belgrade,Beograd,Serbia,11000[223]Institute for Rheumatology /ID# 253174,Belgrade,Beograd,Serbia,11000[224]Institute for Rheumatology /ID# 253175,Belgrade,Beograd,Serbia,11000[225]Clin Hosp Ctr Bezanijska Kosa /ID# 253179,Belgrade,Beograd,Serbia,11080[226]Clinical Center Vojvodina /ID# 253176,Novi Sad,Vojvodina,Serbia,21000[227]"General Hospital ""Djordje Joanovic"" Zrenjanin /ID# 253177,Zrenjanin,Serbia,23101[228]"
ARTROMAC n.o. /ID# 253056,Kosice,Slovakia,040 11[229]MEDMAN s.r.o. /ID# 252950,Martin,Slovakia,036 01[230]Wits Clinical Research Site /ID# 252931,Johannesburg,Gauteng,South Africa,2193[231]University of Pretoria /ID# 252932,Pretoria,Gauteng,South Africa,0001[232]Dr Elsa van Duuren /ID# 254218,Pretoria,Gauteng,South Africa,0002[233]Dr Asokan Naidoo /ID# 253351,Umhlanga,Kwazulu-Natal,South Africa,4319[234]Winelands Medical Research - Somerset West /ID# 254614,Cape Town,Western Cape,South Africa,7130[235]Arthritis Clinical Research Trials /ID# 253349,Cape Town,Western Cape,South Africa,7405[236]Winelands Medical Research Centre /ID# 252934,Stellenbosch,Western Cape,South Africa,7600[237]Hospital Unversitario Marques de Valdecilla /ID# 253120,Santander,Cantabria,Spain,39008[238]Hospital Meixoeiro (CHUVI) /ID# 253124,Vigo,Pontevedra,Spain,36213[239]Hospital Universitario A Coruna - CHUAC /ID# 253123,A Coruna,Spain,15006[240]Hospital Universitario Virgen de Valme /ID# 253121,Sevilla,Spain,41014[241]Universitätsspital Basel /ID# 252907,Basel,Basel-Stadt,Switzerland,4031[242]Kantonsspital St. Gallen /ID# 252906,St. Gallen,Sankt Gallen,Switzerland,9007[243]Inselspital, Universitätsspital Bern /ID# 252909,Bern,Switzerland,3010[244]Chang Gung Mem Hosp Keelung /ID# 253636,Keelung,Taiwan,204[245]China Medical University Hospital /ID# 252936,Taichung City,Taiwan,40447[246]National Taiwan University Hospital /ID# 252937,Taipei City,Taiwan,100[247]Hacettepe Universitesi Tip Fak /ID# 253266,Sihhiye,Ankara,Turkey,06100[248]Gazi Universitesi Tip Fakultes /ID# 252843,Yenimahalle,Ankara,Turkey,06560[249]Sanko Universitesi Hastanesi /ID# 252841,Şehitkamil,Gaziantep,Turkey,27090[250]Akdeniz Universitesi Tip Fakul /ID# 252839,Antalya,Turkey,07059[251]Basaksehir Cam ve Sakura Sehir Hastanesi /ID# 253557,Istanbul,Turkey,34480[252]Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 252844,Istanbul,Turkey,34899[253]Necmettin Erbakan Universitesi /ID# 252837,Meram Konya,Turkey,42080[254]Karadeniz Technical University Farabi Hospital /ID# 252845,Trabzon,Turkey,61080[255]North West Anglia NHS Foundation Trust /ID# 254590,Bretton,Cambridgeshire,United Kingdom,PE3 9GZ[256]Guys and St Thomas NHS Foundation Trust /ID# 252978,London,London, City Of,United Kingdom,SE1 9RT[257]NHS Lothian /ID# 252985,Edinburgh,United Kingdom,EH3 9HE[258]Western Health and Social Care Trust /ID# 254592,Londonderry,United Kingdom,BT47 6SB[259]Portsmouth Hospitals University NHS Trust /ID# 252986,Portsmouth,United Kingdom,PO6 3LY
Systemic Lupus Erythematosus (SLE) is an immune-mediated disease associated with inflammation of multiple organ systems. This study will assess how safe and effective upadacitinib is in treating adult participants with moderately to severely active SLE. Adverse events and change in the disease activity will be assessed. Upadacitinib is an approved drug for rheumatoid arthritis, psoriatic arthritis, and axial spondylarthritis and is being developed for the treatment of SLE. This study is "double-blinded", which means that neither the trial participants nor the study doctors will know who will be given upadacitinib and who will be given placebo (does not contain treatment drug) . This study comprised of 3 sub studies. In Study 1 and Study 2, study doctors put the participants in 1 of the 2 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 2 chance that participants will be assigned to placebo. Eligible participants from Study 1 and Study 2 will enter Study 3 at week 52 to receive specific doses of upadacitinib based on their disease activity and their original treatment assignment in Study 1 or 2. Approximately 500 participants diagnosed with SLE will be enrolled in each of the Study 1 and Study 2 in approximately 320 sites across the world. Participants will receive oral tablets of upadacitinib or matching placebo once daily for 52 weeks in Study 1 and Study 2. Eligible participants from Study 1 and Study 2 will receive oral tablets of upadacitinib once daily for 52 weeks in Study 3. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, checking for side effects and completing questionnaires.
