研究单位：[1]Shanghai Pulmonary Hospital, Shanghai, China[2]Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University,Haikou,Hainan,China,570311[3]Qilu Hospital of Shandong University,Jinan,Shangdong,China[4]Ruijin Hospital,Shanghai,Shanghai,China,200025[5]The Shanghai Fifth People''s Hospital,Shanghai,Shanghai,China,200245[6]Shanghai pulmonary hospital,Shanghai,Shanghai,China,200433[7]Shanxi Bethune Hospital,Taiyuan,Shanxi,China,030032[8]The First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan,China,650032[9]The Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang,China[10]The First People''s Hospital of Anning City Affiliated to Kunming University of Science and Technology,Anning,China[11]Beijing Chao-Yang Hospital, Capital Medical University,Beijing,China[12]Peking Union Medical College Hospital, Chinese Academy of Medical Sciences,Beijing,China[13]Peking University Third Hospital,Beijing,China[14]The First Affiliated Hospital of Jilin University,Changchun,China[15]The Second Xiangya Hospital of Central South University,Changsha,China[16]Xiangya Hospital, Central South University,Changsha,China[17]West China Hospital of Sichuan University,Chengdu,China[18]The Second Affiliated Hospital of Chongqing Medical University,Chongqing,China[19]The Third Affiliated Hospital of Chongqing Medical University,Chongqing,China[20]The Second Affiliated Hospital of Dalian Medical University,Dalian,China[21]Fujian Provincial Hospital,Fuzhou,China[22]The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,China[23]The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou,China[24]Guizhou Provincial People''s Hospital,Guiyang,China[25]The Second Affiliated Hospital of Zhengjiang University,Hangzhou,China[26]Anhui Chest Hospital,Hefei,China[27]The First Affiliated Hospital of Anhui Medical University,Hefei,China[28]Huzhou Central Hospital,Huzhou,China[29]The First Hospital of Jiaxing City,Jiaxing,China[30]The Second Hospital of Jiaxing City,Jiaxing,China[31]The First Affiliated Hospital of Shandong First Medical University,Jinan,China[32]The First Affiliated Hospital of Wenzhou Medical University,Jinan,China[33]The First Affiliated Hospital of Nanchang University,Nanchang,China[34]The Affiliated Sir Run Run Hospital of Nanjing Medical University,Nanjing,China[35]The Second Affiliated Hospital of Nanjing Medical University,Nanjing,China[36]The First Affiliated Hospital of Guangxi Medical University,Nanning,China[37]Affiliated Hospital, Nantong University,Nantong,China[38]The Sixth People''s Hospital of Nantong City,Nantong,China[39]Fenghua District People''s Hospital of Ningbo City,Ningbo,China[40]Ningbo Medical Center Lihuili Hospital,Ningbo,China[41]The First Affiliated Hospital of Ningbo University,Ningbo,China[42]Qingdao Municipal Hospital,Qingdao,China[43]Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai,China[44]Shanghai Eighth People''s Hospital,Shanghai,China[45]Shanghai General Hospital,Shanghai,China[46]Shanghai Putuo District People''s Hospital,Shanghai,China[47]Shanghai Shidong Hospital of Yangpu District,Shanghai,China[48]Shanghai Sixth People''s Hospital,Shanghai,China[49]Shanghai Songjiang District Central Hospital,Shanghai,China[50]Shanghai Yangpu District Central Hospital,Shanghai,China[51]Zhongshan Hospital, Fudan University,Shanghai,China[52]Shangrao People''s Hospital,Shangrao,China[53]Shengjing Hospital of China Medical University,Shenyang,China[54]The First Affiliated Hospital of China Medical University,Shenyang,China[55]Shenzhen Institute of Respiratory Diseases,Shenzhen,China[56]The Eighth Affiliated Hospital of Sun Yat-Sen University,Shenzhen,China[57]Suzhou Science and Technology Town Hospital,Suzhou,China[58]The First Affiliated Hospital of Soochow University,Su
People with bronchiectasis are prone to Pseudomonas aeruginosa (PA) infections, which can become chronic and lead to increased death rates and disease severity. Studies from cystic fibrosis suggest that eradication therapy aimed at PA can successfully transition patients to a culture-negative status, providing long-term benefits. Current guidelines for managing bronchiectasis in adults recommend eradicating PA when it is first or newly isolated; however, there is a lack of randomized controlled trials supporting such recommendations. The researchers hypothesize that both oral ciprofloxacin combined with Tobramycin inhalation solution and Tobramycin inhalation solution alone are superior to no eradication (inhaled saline) in terms of the eradication rates of PA, defined as a negative sputum culture of PA at both 24 weeks and 36 weeks.
